MDSC depletion during immunization with heat-killed Mycobacterium tuberculosis increases protection against BCG infection

MDSC depletion during immunization with heat-killed Mycobacterium tuberculosis increases protection against BCG infection

Tuberculosis (TB) remains one of the deadliest infectious diseases globally. Although the approved human Bacille-Calmette-Guérin (BCG) vaccines provide limited protection, a vaccine based on Mycobacterium tuberculosis (Mtb) has yet to be approved. Our previous findings demonstrated that s.c. immuniz...

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Bibliographic Details
Main Authors: Arpa Aintablian, Anna M. Arold, Haisam Alattar, Laura Cyran, Christoph Schoen, Nelita Du Plessis, Gerhard Walzl, Ulrich Schaible, Andreas Beilhack, Natalie E. Nieuwenhuizen, Manfred B. Lutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
MDSC
Mycobacterium tuberculosis
BCG
vaccines
ATRA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1646526/full
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