Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study
Abstract Background Current evidence on the associations between insulin resistance (IR) and Helicobacter pylori (H. pylori) infection remains limited. This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, t...
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2025-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03610-x |
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| author | Jiayu Qiu Yueming Yu Dingwei Liu Sihai Chen Youhua Wang Jianxiang Peng Jinliang Xie Chengyun Wu Feng Zhou Hui Fang Qirui Lai Yong Xie |
| author_facet | Jiayu Qiu Yueming Yu Dingwei Liu Sihai Chen Youhua Wang Jianxiang Peng Jinliang Xie Chengyun Wu Feng Zhou Hui Fang Qirui Lai Yong Xie |
| author_sort | Jiayu Qiu |
| collection | DOAJ |
| description | Abstract Background Current evidence on the associations between insulin resistance (IR) and Helicobacter pylori (H. pylori) infection remains limited. This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR), and H. pylori infection in U.S. populations. Methods This cross-sectional study involving 939 U.S. participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. The associations between three IR surrogate markers and H. pylori infection were respectively investigated using logistic regression model, restricted cubic spline (RCS) curve and subgroup analysis. Results Three IR surrogate markers levels were significantly elevated in H. pylori infection participants. There was a positive association between three IR surrogate markers and H. pylori infection, even after adjusting for potential confounding variables by three different models. In subgroup analysis, the adjusted association between three IR surrogate markers and H. pylori infection were more likely to be observed in female and Non-Hispanic White. Additionally, the RCS curve revealed a positive linear correlation between TyG index and H. pylori infection across all three models, and between METS-IR and H. pylori infection in Model 3. However, a positive nonlinear correlation was observed between TG/HDL-C ratio and H. pylori infection in all three models. Conclusions These findings suggest that non-insulin-based IR surrogate markers including TyG index, TG/HDL-C ratio, and METS-IR were all positively associated with H. pylori infection. These markers may serve as the potential indicators for identifying the risk of H. pylori infection in U.S. populations. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-6ef58e5fc39b421d99646971f7b01639 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-6ef58e5fc39b421d99646971f7b016392025-01-26T12:36:22ZengBMCBMC Gastroenterology1471-230X2025-01-0125111210.1186/s12876-025-03610-xAssociation between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based studyJiayu Qiu0Yueming Yu1Dingwei Liu2Sihai Chen3Youhua Wang4Jianxiang Peng5Jinliang Xie6Chengyun Wu7Feng Zhou8Hui Fang9Qirui Lai10Yong Xie11Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityJiangxi Medical College, Huan Kui College of Nanchang University, Nanchang UniversityJiangxi Medical College, Huan Kui College of Nanchang University, Nanchang UniversityDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Background Current evidence on the associations between insulin resistance (IR) and Helicobacter pylori (H. pylori) infection remains limited. This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR), and H. pylori infection in U.S. populations. Methods This cross-sectional study involving 939 U.S. participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. The associations between three IR surrogate markers and H. pylori infection were respectively investigated using logistic regression model, restricted cubic spline (RCS) curve and subgroup analysis. Results Three IR surrogate markers levels were significantly elevated in H. pylori infection participants. There was a positive association between three IR surrogate markers and H. pylori infection, even after adjusting for potential confounding variables by three different models. In subgroup analysis, the adjusted association between three IR surrogate markers and H. pylori infection were more likely to be observed in female and Non-Hispanic White. Additionally, the RCS curve revealed a positive linear correlation between TyG index and H. pylori infection across all three models, and between METS-IR and H. pylori infection in Model 3. However, a positive nonlinear correlation was observed between TG/HDL-C ratio and H. pylori infection in all three models. Conclusions These findings suggest that non-insulin-based IR surrogate markers including TyG index, TG/HDL-C ratio, and METS-IR were all positively associated with H. pylori infection. These markers may serve as the potential indicators for identifying the risk of H. pylori infection in U.S. populations. Clinical trial number Not applicable.https://doi.org/10.1186/s12876-025-03610-xTyG indexTG/HDL-C ratioMETS-IRInsulin resistanceHelicobacter pylori infection |
| spellingShingle | Jiayu Qiu Yueming Yu Dingwei Liu Sihai Chen Youhua Wang Jianxiang Peng Jinliang Xie Chengyun Wu Feng Zhou Hui Fang Qirui Lai Yong Xie Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study BMC Gastroenterology TyG index TG/HDL-C ratio METS-IR Insulin resistance Helicobacter pylori infection |
| title | Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study |
| title_full | Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study |
| title_fullStr | Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study |
| title_full_unstemmed | Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study |
| title_short | Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study |
| title_sort | association between non insulin based insulin resistance surrogate makers and helicobacter pylori infection a population based study |
| topic | TyG index TG/HDL-C ratio METS-IR Insulin resistance Helicobacter pylori infection |
| url | https://doi.org/10.1186/s12876-025-03610-x |
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