New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic
Abstract There is limited information on new-onset mental disorders in adults with metabolic diseases following the COVID-19 pandemic. Here, we aimed to examine the changes in mental health following the COVID-19 pandemic and identify factors associated with the development of new-onset mental disor...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-99280-6 |
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| author | Jeong Min Cho Jae-ik Oh Jung Hun Koh Minsang Kim Seung Geun Kim Semin Cho Soojin Lee Yaerim Kim Yong Chul Kim Seung Seok Han Hajeong Lee Kwon-Wook Joo Yon Su Kim Dong Ki Kim Sehoon Park |
| author_facet | Jeong Min Cho Jae-ik Oh Jung Hun Koh Minsang Kim Seung Geun Kim Semin Cho Soojin Lee Yaerim Kim Yong Chul Kim Seung Seok Han Hajeong Lee Kwon-Wook Joo Yon Su Kim Dong Ki Kim Sehoon Park |
| author_sort | Jeong Min Cho |
| collection | DOAJ |
| description | Abstract There is limited information on new-onset mental disorders in adults with metabolic diseases following the COVID-19 pandemic. Here, we aimed to examine the changes in mental health following the COVID-19 pandemic and identify factors associated with the development of new-onset mental disorders. Among 90,580 UK Biobank participants diagnosed with COVID-19 between Jan 31, 2020 and Oct 31, 2022, those who completed both baseline and follow-up mental health questionnaires in 2016–2017 and 2022–2023 were included in the analysis. New-onset depression, anxiety, and alcohol use disorder following the COVID-19 pandemic, as well as changes in mental health scores, were assessed. Furthermore, their association with sociodemographic, clinical, and self-perceived emotional state-related exposures was examined. Prevalent metabolic diseases were significantly associated with a higher risk of new-onset depression (hypertension: odds ratio [OR], 1.22; 95% CI 1.01–1.47; diabetes: OR 1.8; 95% CI 1.25–2.6; obesity: OR 1.66; 95% CI 1.43–1.95) and anxiety (hypertension: OR 1.32; 95% CI 1.06–1.63; diabetes: OR 1.66; 95% CI 1.06–2.62; obesity: OR 1.2; 95% CI 0.99–1.44) following COVID-19 pandemic. There was a significant increase of Patient Health Questionnaire-9 (PHQ-9; beta, 0.32; 95% CI 0.29–0.35) and Generalized Anxiety Disorder-7 (GAD-7; beta, 0.10; 95% CI 0.06–0.13) scores throughout the COVID-19 pandemic, while Alcohol Use Disorder Identification Test (AUDIT) score decreased over time (beta, − 0.24; 95% CI − 0.30 to − 0.18). Preexisting metabolic diseases were associated with the accelerated increase in the PHQ-9 and GAD-7 scores following the pandemic. Adults with metabolic diseases are associated with an increased risk of new-onset depression, anxiety, and alcohol use disorders following the COVID-19 pandemic. |
| format | Article |
| id | doaj-art-6edfcd37e5c8416e8be8b0c56b4af8c9 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-6edfcd37e5c8416e8be8b0c56b4af8c92025-08-20T03:53:12ZengNature PortfolioScientific Reports2045-23222025-05-0115111410.1038/s41598-025-99280-6New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemicJeong Min Cho0Jae-ik Oh1Jung Hun Koh2Minsang Kim3Seung Geun Kim4Semin Cho5Soojin Lee6Yaerim Kim7Yong Chul Kim8Seung Seok Han9Hajeong Lee10Kwon-Wook Joo11Yon Su Kim12Dong Ki Kim13Sehoon Park14Department of Translational Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University HospitalDepartment of Translational Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, Inje University Sanggye Paik HospitalDepartment of Translational Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Uijeongbu Eulji University Medical CenterDepartment of Internal Medicine, Keimyung University School of MedicineDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, Seoul National University HospitalDepartment of Translational Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University HospitalAbstract There is limited information on new-onset mental disorders in adults with metabolic diseases following the COVID-19 pandemic. Here, we aimed to examine the changes in mental health following the COVID-19 pandemic and identify factors associated with the development of new-onset mental disorders. Among 90,580 UK Biobank participants diagnosed with COVID-19 between Jan 31, 2020 and Oct 31, 2022, those who completed both baseline and follow-up mental health questionnaires in 2016–2017 and 2022–2023 were included in the analysis. New-onset depression, anxiety, and alcohol use disorder following the COVID-19 pandemic, as well as changes in mental health scores, were assessed. Furthermore, their association with sociodemographic, clinical, and self-perceived emotional state-related exposures was examined. Prevalent metabolic diseases were significantly associated with a higher risk of new-onset depression (hypertension: odds ratio [OR], 1.22; 95% CI 1.01–1.47; diabetes: OR 1.8; 95% CI 1.25–2.6; obesity: OR 1.66; 95% CI 1.43–1.95) and anxiety (hypertension: OR 1.32; 95% CI 1.06–1.63; diabetes: OR 1.66; 95% CI 1.06–2.62; obesity: OR 1.2; 95% CI 0.99–1.44) following COVID-19 pandemic. There was a significant increase of Patient Health Questionnaire-9 (PHQ-9; beta, 0.32; 95% CI 0.29–0.35) and Generalized Anxiety Disorder-7 (GAD-7; beta, 0.10; 95% CI 0.06–0.13) scores throughout the COVID-19 pandemic, while Alcohol Use Disorder Identification Test (AUDIT) score decreased over time (beta, − 0.24; 95% CI − 0.30 to − 0.18). Preexisting metabolic diseases were associated with the accelerated increase in the PHQ-9 and GAD-7 scores following the pandemic. Adults with metabolic diseases are associated with an increased risk of new-onset depression, anxiety, and alcohol use disorders following the COVID-19 pandemic.https://doi.org/10.1038/s41598-025-99280-6COVID-19Metabolic diseasesMental healthDepressionAnxiety |
| spellingShingle | Jeong Min Cho Jae-ik Oh Jung Hun Koh Minsang Kim Seung Geun Kim Semin Cho Soojin Lee Yaerim Kim Yong Chul Kim Seung Seok Han Hajeong Lee Kwon-Wook Joo Yon Su Kim Dong Ki Kim Sehoon Park New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic Scientific Reports COVID-19 Metabolic diseases Mental health Depression Anxiety |
| title | New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic |
| title_full | New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic |
| title_fullStr | New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic |
| title_full_unstemmed | New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic |
| title_short | New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic |
| title_sort | new onset mental disorders increase among patients with metabolic diseases after the covid 19 pandemic |
| topic | COVID-19 Metabolic diseases Mental health Depression Anxiety |
| url | https://doi.org/10.1038/s41598-025-99280-6 |
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