The ameliorative effect of gallic acid and/or Lasix on topiramate-induced renal impairment in male rats
Background: Topiramate (TPM) is commonly used for migraine prophylaxis; nonetheless, it is linked to nephrotoxicity, which mostly results from oxidative stress and inflammatory mechanisms. Aim: This study aimed to assess the preventive effects of gallic acid (GA) and furosemide (Lasix) against r...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tripoli University
2025-04-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=249146 |
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| Summary: | Background:
Topiramate (TPM) is commonly used for migraine prophylaxis; nonetheless, it is linked to nephrotoxicity, which mostly results from oxidative stress and inflammatory mechanisms.
Aim:
This study aimed to assess the preventive effects of gallic acid (GA) and furosemide (Lasix) against renal damage caused by TPM in rats.
Methods:
Sixty male albino rats were categorized into six groups: control, TPM-only, TPM + Lasix, Lasix-only, TPM + GA, and GA-only. The investigation lasted 60 days, evaluating renal function, oxidative stress indicators, and histological and immunohistochemical alterations.
Results:
The TPM-treated group exhibited considerable renal impairment, as indicated by increased levels of creatinine, urea, blood urea nitrogen (BUN), and interleukin (IL)-6, as well as reduced activity of antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD)). Histopathological examination revealed tubular necrosis and inflammation, whilst immunohistochemistry results showed elevated expression of caspase3 and IL-6. The co-administration of GA or Lasix mitigated these effects. The TPM+GA group exhibited improved kidney function, less oxidative stress, and enhanced histological structure, underscoring GA's powerful antioxidant and anti-inflammatory characteristics. Likewise, Lasix exerted protective effects by alleviating TPM-induced kidney injury.
Conclusion:
These data highlight the therapeutic efficacy of GA and Lasix against TPM-induced nephrotoxicity, indicating their clinical relevance in addressing drug-induced kidney damage. [Open Vet J 2025; 15(4.000): 1823-1835] |
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| ISSN: | 2226-4485 2218-6050 |