Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes
Abstract Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due to poor adherence, short retention time in the mouth, and less‐than‐optimal drug efficacy. In...
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Wiley
2024-12-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202405463 |
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| author | Xiaojing Chen Zhangping Li XinXin Ge Xiaoliang Qi Yajing Xiang Yizuo Shi Ying Li Yao Pan Yingying Wang Yiyu Ru Kelei Huang Jiatan Shao Jianliang Shen He Li |
| author_facet | Xiaojing Chen Zhangping Li XinXin Ge Xiaoliang Qi Yajing Xiang Yizuo Shi Ying Li Yao Pan Yingying Wang Yiyu Ru Kelei Huang Jiatan Shao Jianliang Shen He Li |
| author_sort | Xiaojing Chen |
| collection | DOAJ |
| description | Abstract Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due to poor adherence, short retention time in the mouth, and less‐than‐optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made of a silk fibroin/hyaluronic acid matrix with light‐sensitive adhesive qualities infused with ferric iron/shikonin nanoparticles to enhance healing effects is presented. Initially, this hydrogel forms an adhesive barrier over mucosal lesions through a straightforward local injection, solidifying when exposed to UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination and near‐infrared photothermal bactericidal activity. These characteristics support bacterial elimination and regulate oxidative levels, promoting a wound's progression from inflammation to tissue regeneration. In a diabetic rat model mimicking oral ulcers, FSH3 significantly speeds up healing by adjusting the inflammatory environment of the injured tissue, maintaining balance in oral microbiota, and promoting faster re‐epithelialization. Overall, the light‐sensitive FSH3 hydrogel shows potential for rapid wound recovery and may transform therapeutic methods for managing oral ulcers in diabetes. |
| format | Article |
| id | doaj-art-6ed76b3f8a894a09993aefe6200eded9 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-6ed76b3f8a894a09993aefe6200eded92025-08-20T02:30:27ZengWileyAdvanced Science2198-38442024-12-011145n/an/a10.1002/advs.202405463Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in DiabetesXiaojing Chen0Zhangping Li1XinXin Ge2Xiaoliang Qi3Yajing Xiang4Yizuo Shi5Ying Li6Yao Pan7Yingying Wang8Yiyu Ru9Kelei Huang10Jiatan Shao11Jianliang Shen12He Li13Department of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital Quzhou 324000 ChinaSchool & Hospital of Stomatology Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaNational Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaSchool & Hospital of Stomatology Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaSchool & Hospital of Stomatology Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaZhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 ChinaDepartment of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaDepartment of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaDepartment of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaDepartment of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaDepartment of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaNational Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaDepartment of Otolaryngology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 ChinaAbstract Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due to poor adherence, short retention time in the mouth, and less‐than‐optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made of a silk fibroin/hyaluronic acid matrix with light‐sensitive adhesive qualities infused with ferric iron/shikonin nanoparticles to enhance healing effects is presented. Initially, this hydrogel forms an adhesive barrier over mucosal lesions through a straightforward local injection, solidifying when exposed to UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination and near‐infrared photothermal bactericidal activity. These characteristics support bacterial elimination and regulate oxidative levels, promoting a wound's progression from inflammation to tissue regeneration. In a diabetic rat model mimicking oral ulcers, FSH3 significantly speeds up healing by adjusting the inflammatory environment of the injured tissue, maintaining balance in oral microbiota, and promoting faster re‐epithelialization. Overall, the light‐sensitive FSH3 hydrogel shows potential for rapid wound recovery and may transform therapeutic methods for managing oral ulcers in diabetes.https://doi.org/10.1002/advs.202405463diabeteshydrogelsoral ulcersshikonin, tissue adhesives |
| spellingShingle | Xiaojing Chen Zhangping Li XinXin Ge Xiaoliang Qi Yajing Xiang Yizuo Shi Ying Li Yao Pan Yingying Wang Yiyu Ru Kelei Huang Jiatan Shao Jianliang Shen He Li Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes Advanced Science diabetes hydrogels oral ulcers shikonin, tissue adhesives |
| title | Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes |
| title_full | Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes |
| title_fullStr | Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes |
| title_full_unstemmed | Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes |
| title_short | Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes |
| title_sort | ferric iron shikonin nanoparticle embedded hydrogels with robust adhesion and healing functions for treating oral ulcers in diabetes |
| topic | diabetes hydrogels oral ulcers shikonin, tissue adhesives |
| url | https://doi.org/10.1002/advs.202405463 |
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