Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review
This mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic in vitro studies indicated that...
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| Format: | Article |
| Language: | English |
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Korean Academy of Conservative Dentistry
2023-05-01
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| Series: | Restorative Dentistry & Endodontics |
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| Online Access: | http://www.rde.ac/upload/pdf/rde-48-e20.pdf |
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| author | Dina A. Hammouda Alaa M Mansour Mahmoud A. Saeed Ahmed R. Zaher Mohammed E. Grawish |
| author_facet | Dina A. Hammouda Alaa M Mansour Mahmoud A. Saeed Ahmed R. Zaher Mohammed E. Grawish |
| author_sort | Dina A. Hammouda |
| collection | DOAJ |
| description | This mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic in vitro studies indicated that exosomes enhance the proliferation and migration of mesenchymal cells, as human dental pulp stem cells, via mitogen-activated protein kinases and Wingless-Int signaling pathways. In addition, they possess proangiogenic potential and contribute to neovascularization and capillary tube formation by promoting endothelial cell proliferation and migration of human umbilical vein endothelial cells. Likewise, they regulate the migration and differentiation of Schwann cells, facilitate the conversion of M1 pro-inflammatory macrophages to M2 anti-inflammatory phenotypes, and mediate immune suppression as they promote regulatory T cell conversion. Basic in vivo studies have indicated that exosomes triggered the regeneration of dentin-pulp–like tissue, and exosomes isolated under odontogenic circumstances are particularly strong inducers of tissue regeneration and stem cell differentiation. Exosomes are a promising regenerative tool for DPC in cases of small pulp exposure or for whole-pulp tissue regeneration. |
| format | Article |
| id | doaj-art-6ed4b5af2c5c4aff97544cca0f2ab8f5 |
| institution | Kabale University |
| issn | 2234-7658 2234-7666 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Korean Academy of Conservative Dentistry |
| record_format | Article |
| series | Restorative Dentistry & Endodontics |
| spelling | doaj-art-6ed4b5af2c5c4aff97544cca0f2ab8f52025-08-20T03:29:22ZengKorean Academy of Conservative DentistryRestorative Dentistry & Endodontics2234-76582234-76662023-05-01482e2010.5395/rde.2023.48.e201062Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-reviewDina A. Hammouda0Alaa M Mansour1Mahmoud A. Saeed2Ahmed R. Zaher3Mohammed E. Grawish4Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, EgyptDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, EgyptDepartment of Oral Biology, Faculty of Dentistry, Menoufia University, Shibin el Kom, EgyptDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, EgyptDepartment of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, EgyptThis mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic in vitro studies indicated that exosomes enhance the proliferation and migration of mesenchymal cells, as human dental pulp stem cells, via mitogen-activated protein kinases and Wingless-Int signaling pathways. In addition, they possess proangiogenic potential and contribute to neovascularization and capillary tube formation by promoting endothelial cell proliferation and migration of human umbilical vein endothelial cells. Likewise, they regulate the migration and differentiation of Schwann cells, facilitate the conversion of M1 pro-inflammatory macrophages to M2 anti-inflammatory phenotypes, and mediate immune suppression as they promote regulatory T cell conversion. Basic in vivo studies have indicated that exosomes triggered the regeneration of dentin-pulp–like tissue, and exosomes isolated under odontogenic circumstances are particularly strong inducers of tissue regeneration and stem cell differentiation. Exosomes are a promising regenerative tool for DPC in cases of small pulp exposure or for whole-pulp tissue regeneration.http://www.rde.ac/upload/pdf/rde-48-e20.pdfdental pulpdental pulp cappingdentinexosomesregenerative endodonticsstem cells |
| spellingShingle | Dina A. Hammouda Alaa M Mansour Mahmoud A. Saeed Ahmed R. Zaher Mohammed E. Grawish Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review Restorative Dentistry & Endodontics dental pulp dental pulp capping dentin exosomes regenerative endodontics stem cells |
| title | Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review |
| title_full | Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review |
| title_fullStr | Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review |
| title_full_unstemmed | Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review |
| title_short | Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review |
| title_sort | stem cell derived exosomes for dentin pulp complex regeneration a mini review |
| topic | dental pulp dental pulp capping dentin exosomes regenerative endodontics stem cells |
| url | http://www.rde.ac/upload/pdf/rde-48-e20.pdf |
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