The scaffold protein DLG4 facilitates RNF63-mediated ubiquitination and degradation of STAT3 in non-small cell lung cancer

The scaffold protein DLG4 facilitates RNF63-mediated ubiquitination and degradation of STAT3 in non-small cell lung cancer

Abstract Background The Disks-large homolog (DLG) family has been found to govern multiple key processes in human cancers. However, their role in non-small cell lung cancer (NSCLC) remains unknown. Methods The expression of DLG4 was determined by immunoblotting and q-PCR. The interacting proteins of...

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Bibliographic Details
Main Authors: Shisong Chen, Hongjie Xu, Ning Li, Yang Yang, Ruxi Pang, Shuwei Zhang, Junjie Qiao, Hao Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
NSCLC
DLG4
RNF63
STAT3
Online Access:https://doi.org/10.1186/s12964-025-02334-5
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