CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling
Abstract CD146 plays a key role in cancer progression and metastasis. Cancer stem cells (CSCs) are responsible for tumor initiation, drug resistance, metastasis, and recurrence. In this study, we explored the role of CD146 in the regulation of liver CSCs. Here, we demonstrated that CD146 was highly...
Saved in:
| Main Authors: | Bing Yan, QiuYu Lu, TianMing Gao, KunQing Xiao, QianNi Zong, HongWei Lv, GuiShuai Lv, Liang Wang, ChunYing Liu, Wen Yang, GuoQing Jiang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-03-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07470-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation
by: Syeda Nayab Fatima Abidi, et al.
Published: (2024-11-01) -
”Jag tar varken kristendom eller islam på allvar, jag går efter vad jag själv tycker”
by: Boel Westerberg
Published: (2007-09-01) -
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.
by: Victoria Emuss, et al.
Published: (2009-10-01) -
CSF2 promotes chemoresistance in colorectal cancer by regulating Notch pathway
by: Hairong Zhou, et al.
Published: (2025-04-01) -
M1-Polarized Macrophages Promote Self-Renewing Phenotype of Hepatic Progenitor Cells with Jagged1-Notch Signalling Involved: Relevance in Primary Sclerosing Cholangitis
by: Heli Li, et al.
Published: (2018-01-01)