CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling

Abstract CD146 plays a key role in cancer progression and metastasis. Cancer stem cells (CSCs) are responsible for tumor initiation, drug resistance, metastasis, and recurrence. In this study, we explored the role of CD146 in the regulation of liver CSCs. Here, we demonstrated that CD146 was highly...

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Main Authors: Bing Yan, QiuYu Lu, TianMing Gao, KunQing Xiao, QianNi Zong, HongWei Lv, GuiShuai Lv, Liang Wang, ChunYing Liu, Wen Yang, GuoQing Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07470-x
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