Human Gut Microbes Associated with Systolic Blood Pressure
Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communi...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2022/2923941 |
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| author | Tulsi Kumari Joishy Aashish Jha Mai Oudah Santanu Das Atanu Adak Dibyayan Deb Mojibur Rohman Khan |
| author_facet | Tulsi Kumari Joishy Aashish Jha Mai Oudah Santanu Das Atanu Adak Dibyayan Deb Mojibur Rohman Khan |
| author_sort | Tulsi Kumari Joishy |
| collection | DOAJ |
| description | Emerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. Cardiovascular diseases are the leading cause of mortality in India affecting 55 million people, and high blood pressure is one of the primary risk factors for cardiovascular diseases. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. Moreover, several genera previously associated with hypertension in non-Indian populations were also associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. These findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India. |
| format | Article |
| id | doaj-art-6eccec66b2c04aba88574200c9cc36dd |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-6eccec66b2c04aba88574200c9cc36dd2025-02-03T01:00:47ZengWileyInternational Journal of Hypertension2090-03922022-01-01202210.1155/2022/2923941Human Gut Microbes Associated with Systolic Blood PressureTulsi Kumari Joishy0Aashish Jha1Mai Oudah2Santanu Das3Atanu Adak4Dibyayan Deb5Mojibur Rohman Khan6Molecular Biology and Microbial Biotechnology LaboratoryGenome Heritage GroupProgram of Computer ScienceMolecular Biology and Microbial Biotechnology LaboratoryMolecular Biology and Microbial Biotechnology LaboratoryMolecular Biology and Microbial Biotechnology LaboratoryMolecular Biology and Microbial Biotechnology LaboratoryEmerging studies have revealed a strong link between the gut microbiome and several human diseases. Since human gut microbiome mirrors variations in lifestyle and environment, whether associations between disease conditions and gut microbiome are consistent across populations—particularly in communities practicing traditional subsistence strategies whose microbiomes differ markedly from industrialists—remains unknown. Cardiovascular diseases are the leading cause of mortality in India affecting 55 million people, and high blood pressure is one of the primary risk factors for cardiovascular diseases. We examined associations between gut microbiome and blood pressure along with 14 other variables associated with lifestyle, dietary habits, disease conditions, and clinical blood markers in the three Assamese populations. Our analysis reveals a robust link between the gut microbiome diversity and composition and systolic blood pressure. Moreover, several genera previously associated with hypertension in non-Indian populations were also associated with systolic blood pressure in this cohort and these genera were predictors of elevated blood pressure in these populations. These findings confer opportunities to design personalized, preventative, and targeted interventions harnessing the gut microbiome to tackle the burden of cardiovascular diseases in India.http://dx.doi.org/10.1155/2022/2923941 |
| spellingShingle | Tulsi Kumari Joishy Aashish Jha Mai Oudah Santanu Das Atanu Adak Dibyayan Deb Mojibur Rohman Khan Human Gut Microbes Associated with Systolic Blood Pressure International Journal of Hypertension |
| title | Human Gut Microbes Associated with Systolic Blood Pressure |
| title_full | Human Gut Microbes Associated with Systolic Blood Pressure |
| title_fullStr | Human Gut Microbes Associated with Systolic Blood Pressure |
| title_full_unstemmed | Human Gut Microbes Associated with Systolic Blood Pressure |
| title_short | Human Gut Microbes Associated with Systolic Blood Pressure |
| title_sort | human gut microbes associated with systolic blood pressure |
| url | http://dx.doi.org/10.1155/2022/2923941 |
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