A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment.

<h4>Aims</h4>β-amyloid (Aβ) plaques are a key feature of Alzheimer's disease pathology but correlate poorly with dementia. They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil. This study characterised the astrocyte response to Aβ plaque...

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Bibliographic Details
Main Authors: Ryan Mathur, Paul G Ince, Thais Minett, Claire J Garwood, Pamela J Shaw, Fiona E Matthews, Carol Brayne, Julie E Simpson, Stephen B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118463&type=printable
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