Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance?
It has been given current information about acute and late adverse reactions arising from the use of gadolinium magnetic resonance contrast agents (GMRCA). The role of thermodynamic and kinetic stability GMRCA in the deposition of gadolinium in tissues, including the brain, the development of pseudo...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Luchevaya Diagnostika, LLC
2016-09-01
|
| Series: | Вестник рентгенологии и радиологии |
| Subjects: | |
| Online Access: | https://www.russianradiology.ru/jour/article/view/159 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850065769450176512 |
|---|---|
| author | V. O. Panov N. L. Shimanovskiy |
| author_facet | V. O. Panov N. L. Shimanovskiy |
| author_sort | V. O. Panov |
| collection | DOAJ |
| description | It has been given current information about acute and late adverse reactions arising from the use of gadolinium magnetic resonance contrast agents (GMRCA). The role of thermodynamic and kinetic stability GMRCA in the deposition of gadolinium in tissues, including the brain, the development of pseudohypoglycemia and nephrogenic systemic fibrosis (NSF) is considerated. After analysis of data on mechanisms of deposition of gadolinium in the body's cells and mechanisms of cytotoxicity on the chemical structure of existing GMRCA it is concluded that for reducing the accumulation of gadolinium in cells and the risk of development of NSF is advisable to use stable macrocyclic agents such as gadobutrol. |
| format | Article |
| id | doaj-art-6ec5fdeb5e7a4d398a73b1eb5fc2555f |
| institution | DOAJ |
| issn | 0042-4676 2619-0478 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj-art-6ec5fdeb5e7a4d398a73b1eb5fc2555f2025-08-20T02:48:54ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782016-09-0197424325610.20862/0042-4676-2016-97-4-243-256139Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance?V. O. Panov0N. L. Shimanovskiy1Russian Medical Academy of Postgraduate Education, Ministry of Health of the RFN.I. Pirogov Russian National Research Medical University, Ministry of Health of the RFIt has been given current information about acute and late adverse reactions arising from the use of gadolinium magnetic resonance contrast agents (GMRCA). The role of thermodynamic and kinetic stability GMRCA in the deposition of gadolinium in tissues, including the brain, the development of pseudohypoglycemia and nephrogenic systemic fibrosis (NSF) is considerated. After analysis of data on mechanisms of deposition of gadolinium in the body's cells and mechanisms of cytotoxicity on the chemical structure of existing GMRCA it is concluded that for reducing the accumulation of gadolinium in cells and the risk of development of NSF is advisable to use stable macrocyclic agents such as gadobutrol.https://www.russianradiology.ru/jour/article/view/159gadolinium magnetic resonance contrast agentsstabilitydeposition of gadoliniumgadobutrol |
| spellingShingle | V. O. Panov N. L. Shimanovskiy Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance? Вестник рентгенологии и радиологии gadolinium magnetic resonance contrast agents stability deposition of gadolinium gadobutrol |
| title | Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance? |
| title_full | Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance? |
| title_fullStr | Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance? |
| title_full_unstemmed | Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance? |
| title_short | Нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance? |
| title_sort | нas the stability of gadoliniumbased magnetic resonance contrast media the clinical significance |
| topic | gadolinium magnetic resonance contrast agents stability deposition of gadolinium gadobutrol |
| url | https://www.russianradiology.ru/jour/article/view/159 |
| work_keys_str_mv | AT vopanov nasthestabilityofgadoliniumbasedmagneticresonancecontrastmediatheclinicalsignificance AT nlshimanovskiy nasthestabilityofgadoliniumbasedmagneticresonancecontrastmediatheclinicalsignificance |