Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia
Introduction: Data on blood-borne viral infections in some regions in Saudi Arabia remain scarce. This study investigates the prevalence of serological markers and nucleic acid for blood-borne viruses among blood donors in Al-Baha, Kingdom of Saudi Arabia. Methodology: In this cross-sectional study...
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The Journal of Infection in Developing Countries
2016-06-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/6666 |
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| author | Hatem H AlMutairi Mohammad M AlAhmari Badr H Al-Zahran Ibrahim S Abbas Juma`an S Al Ghamdi Yahia A Raja`a Talal A Sallam |
| author_facet | Hatem H AlMutairi Mohammad M AlAhmari Badr H Al-Zahran Ibrahim S Abbas Juma`an S Al Ghamdi Yahia A Raja`a Talal A Sallam |
| author_sort | Hatem H AlMutairi |
| collection | DOAJ |
| description | Introduction: Data on blood-borne viral infections in some regions in Saudi Arabia remain scarce. This study investigates the prevalence of serological markers and nucleic acid for blood-borne viruses among blood donors in Al-Baha, Kingdom of Saudi Arabia.
Methodology: In this cross-sectional study, 2,807 donors who donated blood between January 2009 and November 2011 were investigated for blood-borne viral serological markers including HBsAg, anti-HBc, anti-HBs, anti-HCV, anti-HIV, and anti-HTLVI/III in addition to viral nucleic acid.
Results: All donors were males between 16 to 66 years of age (mean: 31.5 ± 9.3 years). Viral nucleic acid and/or serological markers were detected in a total of 36 (1.3%) donors; of them, 26 (72.2%) had nucleic acid concomitant with serological markers, 6 (16.7%) had only viral nucleic acid, while 4 (11.1%) had only serological markers. Of all donors, 22 (0.8%) had HBsAg, 227 (8.0%) had anti-HBc, 157 (5.0%) had anti-HBs, 2,577 (91.8%) had no HBV markers, 2 (0.07%) had anti-HIV, 1 (0.04%) had anti-HCV, and 1 (0.04%) had anti-HTLVI/II. The donors who were born during HBV vaccination era showed no HBsAg (0.0%; p = 0.052), lower rates of anti-HBc (1.5%; p < 0.001) and anti-HBs (0.7%; p < 0.001), while the majority had no HBV markers (98.5%; p < 0.001).
Conclusions: Combined viral nucleic acid and serological testing of donated blood enhances blood safety. The absence of HBV markers among donors suggests susceptibility or declined anti-HBs levels. Thus, HBV revaccination or a vaccine boost among adolescents and adults might be indispensable.
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| format | Article |
| id | doaj-art-6ec0b9f8221c472a8bbadba2f965a065 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6ec0b9f8221c472a8bbadba2f965a0652025-08-20T02:27:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802016-06-01100610.3855/jidc.6666Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi ArabiaHatem H AlMutairi0Mohammad M AlAhmari1Badr H Al-Zahran2Ibrahim S Abbas3Juma`an S Al Ghamdi4Yahia A Raja`a5Talal A Sallam6Central Laboratory and Blood Bank, Riyadh, Saudi ArabiaKhamis Mushait General Hospital, Khamis Mushait, Saudi ArabiaCentral Laboratory and Blood Bank, Al-Baha, Saudi ArabiaHealth Affairs Office, Al-Baha, Saudi ArabiaPrimary Health Care Centre, Bani Farwa, Al-Baha, Saudi ArabiaFaculty of Public Health and Health Informatics, Umm Al-Qura University, Makkah, Saudi ArabiaFaculty of Medicine, Al-Baha University Al-Baha, Saudi ArabiaIntroduction: Data on blood-borne viral infections in some regions in Saudi Arabia remain scarce. This study investigates the prevalence of serological markers and nucleic acid for blood-borne viruses among blood donors in Al-Baha, Kingdom of Saudi Arabia. Methodology: In this cross-sectional study, 2,807 donors who donated blood between January 2009 and November 2011 were investigated for blood-borne viral serological markers including HBsAg, anti-HBc, anti-HBs, anti-HCV, anti-HIV, and anti-HTLVI/III in addition to viral nucleic acid. Results: All donors were males between 16 to 66 years of age (mean: 31.5 ± 9.3 years). Viral nucleic acid and/or serological markers were detected in a total of 36 (1.3%) donors; of them, 26 (72.2%) had nucleic acid concomitant with serological markers, 6 (16.7%) had only viral nucleic acid, while 4 (11.1%) had only serological markers. Of all donors, 22 (0.8%) had HBsAg, 227 (8.0%) had anti-HBc, 157 (5.0%) had anti-HBs, 2,577 (91.8%) had no HBV markers, 2 (0.07%) had anti-HIV, 1 (0.04%) had anti-HCV, and 1 (0.04%) had anti-HTLVI/II. The donors who were born during HBV vaccination era showed no HBsAg (0.0%; p = 0.052), lower rates of anti-HBc (1.5%; p < 0.001) and anti-HBs (0.7%; p < 0.001), while the majority had no HBV markers (98.5%; p < 0.001). Conclusions: Combined viral nucleic acid and serological testing of donated blood enhances blood safety. The absence of HBV markers among donors suggests susceptibility or declined anti-HBs levels. Thus, HBV revaccination or a vaccine boost among adolescents and adults might be indispensable. https://jidc.org/index.php/journal/article/view/6666HBVHCVHIVAl-BahaKSAblood donors |
| spellingShingle | Hatem H AlMutairi Mohammad M AlAhmari Badr H Al-Zahran Ibrahim S Abbas Juma`an S Al Ghamdi Yahia A Raja`a Talal A Sallam Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia Journal of Infection in Developing Countries HBV HCV HIV Al-Baha KSA blood donors |
| title | Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia |
| title_full | Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia |
| title_fullStr | Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia |
| title_full_unstemmed | Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia |
| title_short | Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia |
| title_sort | prevalence of serological markers and nucleic acid for blood borne viral infections in blood donors in al baha saudi arabia |
| topic | HBV HCV HIV Al-Baha KSA blood donors |
| url | https://jidc.org/index.php/journal/article/view/6666 |
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