REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP
Aim. To assess long-term outcomes in patients after acute stroke within LIS-2 registry.Material and methods. 960 patients hospitalized in 2009-2011 due to acute stroke in one of the district hospitals of Lyubertsy town were included into analysis. The first assessment of the life status was carried...
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Столичная издательская компания
2018-05-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1657 |
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| author | S. Yu. Martsevich N. P. Kutishenko A. V. Zagrebelnyy Yu. V. Lukina М. L. Ginzburg A. V. Fokina E. V. Daniels A. D. Deev |
| author_facet | S. Yu. Martsevich N. P. Kutishenko A. V. Zagrebelnyy Yu. V. Lukina М. L. Ginzburg A. V. Fokina E. V. Daniels A. D. Deev |
| author_sort | S. Yu. Martsevich |
| collection | DOAJ |
| description | Aim. To assess long-term outcomes in patients after acute stroke within LIS-2 registry.Material and methods. 960 patients hospitalized in 2009-2011 due to acute stroke in one of the district hospitals of Lyubertsy town were included into analysis. The first assessment of the life status was carried out in 2012-2013 through 2.8 [2.1; 3.5] years after discharge, and a reassessment was in 2017 through 7-8 years after discharge, median follow-up 6.1 [6.9; 7.7] years. The primary endpoint was total mortality. Survival was assessed using the Kaplan-Meier curves.Results. Only 300 patients were alive by the end of the follow-up, 543 patients died, and life status of 117 patients were unknown. Kaplan-Mayer curves showed that mortality was the highest during the first year after stroke, and then it stabilized and remained unchanged till the end of the followup. Less than a third of patients were alive after 8 years of follow-up. The identification of causes of death was difficult in a significant number of cases (in 52% of cases the cause was unknown). Acute stroke and other cerebrovascular diseases, as causes of death, were found in 15% of deaths, other cardiovascular diseases – in 18%, oncological diseases – in 7%, injuries – in 4%. Such causes of death as acute myocardial infarction, pulmonary disease or pulmonary embolism accounted for only 2% in the structure of deaths. A trend towards decrease in the proportion of recurrent stroke as the cause of death was observed as the follow-up period increases.Conclusion. Mortality rate of patients after acute stroke remains stably high throughout the follow-up period: after 8 years less than a third of patients were alive. Death from acute stroke and cardiovascular diseases prevailed among the main causes of death at a distant stage of observation. It is necessary to analyze the factors determining the long-term outcomes at different periods after the stroke. |
| format | Article |
| id | doaj-art-6ebf7d07ee84400aa8b1030877ecb9d1 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-6ebf7d07ee84400aa8b1030877ecb9d12025-08-23T10:00:29ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532018-05-0114226026510.20996/1819-6446-2018-14-2-260-2651469REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UPS. Yu. Martsevich0N. P. Kutishenko1A. V. Zagrebelnyy2Yu. V. Lukina3М. L. Ginzburg4A. V. Fokina5E. V. Daniels6A. D. Deev7National Medical Research Center for Preventive MedicineNational Medical Research Center for Preventive MedicineNational Medical Research Center for Preventive MedicineNational Medical Research Center for Preventive MedicineLyubertsy District Hospital №2Lyubertsy District Hospital №2Lyubertsy District Hospital №2National Medical Research Center for Preventive MedicineAim. To assess long-term outcomes in patients after acute stroke within LIS-2 registry.Material and methods. 960 patients hospitalized in 2009-2011 due to acute stroke in one of the district hospitals of Lyubertsy town were included into analysis. The first assessment of the life status was carried out in 2012-2013 through 2.8 [2.1; 3.5] years after discharge, and a reassessment was in 2017 through 7-8 years after discharge, median follow-up 6.1 [6.9; 7.7] years. The primary endpoint was total mortality. Survival was assessed using the Kaplan-Meier curves.Results. Only 300 patients were alive by the end of the follow-up, 543 patients died, and life status of 117 patients were unknown. Kaplan-Mayer curves showed that mortality was the highest during the first year after stroke, and then it stabilized and remained unchanged till the end of the followup. Less than a third of patients were alive after 8 years of follow-up. The identification of causes of death was difficult in a significant number of cases (in 52% of cases the cause was unknown). Acute stroke and other cerebrovascular diseases, as causes of death, were found in 15% of deaths, other cardiovascular diseases – in 18%, oncological diseases – in 7%, injuries – in 4%. Such causes of death as acute myocardial infarction, pulmonary disease or pulmonary embolism accounted for only 2% in the structure of deaths. A trend towards decrease in the proportion of recurrent stroke as the cause of death was observed as the follow-up period increases.Conclusion. Mortality rate of patients after acute stroke remains stably high throughout the follow-up period: after 8 years less than a third of patients were alive. Death from acute stroke and cardiovascular diseases prevailed among the main causes of death at a distant stage of observation. It is necessary to analyze the factors determining the long-term outcomes at different periods after the stroke.https://www.rpcardio.online/jour/article/view/1657strokeregistrylong-term follow-upmortality |
| spellingShingle | S. Yu. Martsevich N. P. Kutishenko A. V. Zagrebelnyy Yu. V. Lukina М. L. Ginzburg A. V. Fokina E. V. Daniels A. D. Deev REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP Рациональная фармакотерапия в кардиологии stroke registry long-term follow-up mortality |
| title | REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP |
| title_full | REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP |
| title_fullStr | REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP |
| title_full_unstemmed | REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP |
| title_short | REGISTRY OF ACUTE CEREBRAL CIRCULATORY DISORDERS LIS-2: NEW DATA ON LONG-TERM FOLLOW-UP |
| title_sort | registry of acute cerebral circulatory disorders lis 2 new data on long term follow up |
| topic | stroke registry long-term follow-up mortality |
| url | https://www.rpcardio.online/jour/article/view/1657 |
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