A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab
Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by blood and tissue eosinophilia with eosinophil-driven tissue damage most commonly affecting the skin, lungs, and gastrointestinal tract and to a lesser degree the cardiovascular and coagulation systems. We discuss a case of I...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-02-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0978 |
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| author | Emily Jezewski Bryant R. England Jill A. Poole Cory Rohlfsen |
| author_facet | Emily Jezewski Bryant R. England Jill A. Poole Cory Rohlfsen |
| author_sort | Emily Jezewski |
| collection | DOAJ |
| description | Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by blood and tissue eosinophilia with eosinophil-driven tissue damage most commonly affecting the skin, lungs, and gastrointestinal tract and to a lesser degree the cardiovascular and coagulation systems. We discuss a case of IHES in a 62-year-old man who presented with serositis-predominant symptoms including ascites, pleural effusion, and an inflammatory polyarthritis with 6.0 × 109 eosinophils per liter with exclusion of other conditions to explain disease. This was a unique case of IHES with serositis at presentation without detectable autoimmune serologies and adds to the variability of a heterogeneous group of disorders with inadequately understood pathology. |
| format | Article |
| id | doaj-art-6ebf0d6c7e454e65987f3fd7bc9868a7 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-6ebf0d6c7e454e65987f3fd7bc9868a72025-08-20T02:27:20ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-02-013210.7326/aimcc.2023.0978A Case of Hypereosinophilia With Serositis Responsive to MepolizumabEmily Jezewski0Bryant R. England1Jill A. Poole2Cory Rohlfsen31College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska2Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, Nebraska4Department of Internal Medicine, Division of Allergy and Immunology, University of Nebraska Medical Center, Omaha, Nebraska5Department of Internal Medicine, Division of General Medicine, University of Nebraska Medical Center, Omaha, NebraskaIdiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by blood and tissue eosinophilia with eosinophil-driven tissue damage most commonly affecting the skin, lungs, and gastrointestinal tract and to a lesser degree the cardiovascular and coagulation systems. We discuss a case of IHES in a 62-year-old man who presented with serositis-predominant symptoms including ascites, pleural effusion, and an inflammatory polyarthritis with 6.0 × 109 eosinophils per liter with exclusion of other conditions to explain disease. This was a unique case of IHES with serositis at presentation without detectable autoimmune serologies and adds to the variability of a heterogeneous group of disorders with inadequately understood pathology.https://www.acpjournals.org/doi/10.7326/aimcc.2023.0978 |
| spellingShingle | Emily Jezewski Bryant R. England Jill A. Poole Cory Rohlfsen A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab Annals of Internal Medicine: Clinical Cases |
| title | A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab |
| title_full | A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab |
| title_fullStr | A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab |
| title_full_unstemmed | A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab |
| title_short | A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab |
| title_sort | case of hypereosinophilia with serositis responsive to mepolizumab |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0978 |
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