A Case of Hypereosinophilia With Serositis Responsive to Mepolizumab
Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by blood and tissue eosinophilia with eosinophil-driven tissue damage most commonly affecting the skin, lungs, and gastrointestinal tract and to a lesser degree the cardiovascular and coagulation systems. We discuss a case of I...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-02-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0978 |
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| Summary: | Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by blood and tissue eosinophilia with eosinophil-driven tissue damage most commonly affecting the skin, lungs, and gastrointestinal tract and to a lesser degree the cardiovascular and coagulation systems. We discuss a case of IHES in a 62-year-old man who presented with serositis-predominant symptoms including ascites, pleural effusion, and an inflammatory polyarthritis with 6.0 × 109 eosinophils per liter with exclusion of other conditions to explain disease. This was a unique case of IHES with serositis at presentation without detectable autoimmune serologies and adds to the variability of a heterogeneous group of disorders with inadequately understood pathology. |
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| ISSN: | 2767-7664 |