Therapeutic gene targets and epigenetic modifications in rheumatoid arthritis: Insights from MTX, JAK inhibitors, and LLDT-8

Therapeutic gene targets and epigenetic modifications in rheumatoid arthritis: Insights from MTX, JAK inhibitors, and LLDT-8

Objective: This study investigates therapeutic gene targets and their epigenetic modifications in rheumatoid arthritis (RA), focusing on the molecular effects of methotrexate (MTX), Janus kinase (JAK) inhibitors, and (5R)-5-hydroxytriptolide (LLDT-8) on fibroblast-like synoviocytes (FLS). Methods: P...

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Bibliographic Details
Main Authors: Jianan Zhao, Yunshen Li, Runrun Zhang, Yu Shan, Chenyang Song, Yaxin Cheng, Yiming Shi, Yixin Zheng, Fuyu Zhao, Junyu Fan, Cen Chang, Yuejuan Zheng, Dongyi He
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Rheumatoid arthritis
Methotrexate
JAK inhibitor
LLDT-8
Fibroblast-like synoviocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825001256
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