The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort
<b>Introduction:</b> This study aims to investigate the clinical impact of Omicron Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection on the clinical presentation of Coronavirus Disease 2019 (COVID-19) in the very old (≥80 years old) population. <b>Methods:</...
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2025-06-01
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| author | Pierantonio Grimaldi Mariantonietta Pisaturo Antonio Russo Salvatore Martini Francesca Ambrisi Filomena Milite Giovanni Di Caprio Fabio Giuliano Numis Ivan Gentile Vincenzo Sangiovanni Vincenzo Esposito Rossella Pacilio Giosuele Calabria Raffaella Pisapia Canio Carriero Alfonso Masullo Elio Manzillo Grazia Russo Roberto Parrella Sebastiano Leone Michele Gambardella Antonio Ponticiello Nicola Coppola |
| author_facet | Pierantonio Grimaldi Mariantonietta Pisaturo Antonio Russo Salvatore Martini Francesca Ambrisi Filomena Milite Giovanni Di Caprio Fabio Giuliano Numis Ivan Gentile Vincenzo Sangiovanni Vincenzo Esposito Rossella Pacilio Giosuele Calabria Raffaella Pisapia Canio Carriero Alfonso Masullo Elio Manzillo Grazia Russo Roberto Parrella Sebastiano Leone Michele Gambardella Antonio Ponticiello Nicola Coppola |
| author_sort | Pierantonio Grimaldi |
| collection | DOAJ |
| description | <b>Introduction:</b> This study aims to investigate the clinical impact of Omicron Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection on the clinical presentation of Coronavirus Disease 2019 (COVID-19) in the very old (≥80 years old) population. <b>Methods:</b> All patients aged 80 years or older, hospitalized from March 2020 to June 2023 with a SARS-CoV-2 infection in one of the 17 COVID-19 units in eight cities of Campania, southern Italy, were enrolled in a multicenter, observational, retrospective study. <b>Results:</b> 341 patients ≥ 80 years of age were included: 80 of them in the Omicron and 261 in the non-Omicron period. Patients admitted during the Omicron period were older (<i>p</i> = 0.0001) and more comorbid, showing more frequently arterial hypertension (<i>p</i> = 0.018), cardiovascular disease (<i>p</i> = 0.0001), chronic kidney disease (CKD) (<i>p</i> = 0.002), chronic obstructive pulmonary disease (COPD) (<i>p</i> = 0.001), and active cancer (<i>p</i> = 0.0001). Severe and critical outcomes were observed more often in the non-Omicron variant (<i>p</i> = 0.0001). Patients in the Omicron group did not show a significantly prolonged hospitalization time (<i>p</i> = 0.063) or a higher likelihood of death during hospitalization (<i>p</i> = 0.097). <b>Discussion:</b> In our study, despite the greater frailty of patients hospitalized during the Omicron period, the disease appeared less severe compared to previous waves, suggesting that the lower severity of the disease could be attributed to virological rather than population characteristics. These findings underscore the importance of prevention strategies for older people, as the administration of vaccination and early antiviral therapies in at-risk subjects. |
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| institution | Kabale University |
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| spelling | doaj-art-6eba02f9b5f347d79712be1aa5cea7372025-08-20T03:36:31ZengMDPI AGBiomedicines2227-90592025-06-01137156310.3390/biomedicines13071563The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp CohortPierantonio Grimaldi0Mariantonietta Pisaturo1Antonio Russo2Salvatore Martini3Francesca Ambrisi4Filomena Milite5Giovanni Di Caprio6Fabio Giuliano Numis7Ivan Gentile8Vincenzo Sangiovanni9Vincenzo Esposito10Rossella Pacilio11Giosuele Calabria12Raffaella Pisapia13Canio Carriero14Alfonso Masullo15Elio Manzillo16Grazia Russo17Roberto Parrella18Sebastiano Leone19Michele Gambardella20Antonio Ponticiello21Nicola Coppola22Department of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80131 Naples, ItalyDepartment of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80131 Naples, ItalyDepartment of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80131 Naples, ItalyInfectious Disease Unit, A.O.U. Luigi Vanvitelli, 80138 Naples, ItalyDepartment of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80131 Naples, ItalyDepartment of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80131 Naples, ItalyInfectious Disease Unit, A.O.S Anna e S Sebastiano Caserta, 81100 Caserta, ItalyEmergency Unit, P.O. Santa Maria delle Grazie, 80078 Pozzuoli, ItalyInfectious Disease Unit, University Federico II, 80125 Naples, ItalyThird Infectious Disease Unit, P.O. Cotugno, A.O.R.N. dei Colli, 80131 Naples, ItalyInfectious Diseases Unit and Gender Medicine, P.O. Cotugno, AORN dei Colli, 80131 Naples, ItalyHepatic Infectious Disease Unit, P.O. Cotugno, A.O.R.N. dei Colli, 80131 Naples, ItalyIX Infectious Disease Unit, P.O. Cotugno, A.O.R.N. dei Coli, 80131 Naples, ItalyFirst Infectious Disease Unit, P.O. Cotugno, A.O.R.N. dei Coli, 80131 Naples, ItalyInfectious Disease Unit, P.O. Rummo, A.O. San Pio, 82100 Benevento, ItalyInfectious Disease Unit, A.O. San Giovanni di Dio e Ruggi D’Aragona Salerno, 84131 Salerno, ItalyVIII Infectious Disease Unit, P.O. Cotugno, A.O.R.N. dei Coli, 80131 Naples, ItalyInfectious Disease Unit, Ospedale Maria S.S. Addolorata di Eboli, A.S.L. Salerno, 84131 Salerno, ItalyRespiratory Infectious Disease Unit, P.O. Cotugno, A.O.R.N. dei Colli, 80131 Naples, ItalyInfectious Disease Unit, A.O. Avellino, 83100 Avellino, ItalyInfectious Disease Unit, P.O. S. Luca, Vallo della Lucania, A.S.L. Salerno, 84131 Salerno, ItalyPneumology Unit, A.O.R.N. Caserta, 81100 Caserta, ItalyDepartment of Mental Health and Public Medicine, University of Campania “L. Vanvitelli”, 80131 Naples, Italy<b>Introduction:</b> This study aims to investigate the clinical impact of Omicron Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection on the clinical presentation of Coronavirus Disease 2019 (COVID-19) in the very old (≥80 years old) population. <b>Methods:</b> All patients aged 80 years or older, hospitalized from March 2020 to June 2023 with a SARS-CoV-2 infection in one of the 17 COVID-19 units in eight cities of Campania, southern Italy, were enrolled in a multicenter, observational, retrospective study. <b>Results:</b> 341 patients ≥ 80 years of age were included: 80 of them in the Omicron and 261 in the non-Omicron period. Patients admitted during the Omicron period were older (<i>p</i> = 0.0001) and more comorbid, showing more frequently arterial hypertension (<i>p</i> = 0.018), cardiovascular disease (<i>p</i> = 0.0001), chronic kidney disease (CKD) (<i>p</i> = 0.002), chronic obstructive pulmonary disease (COPD) (<i>p</i> = 0.001), and active cancer (<i>p</i> = 0.0001). Severe and critical outcomes were observed more often in the non-Omicron variant (<i>p</i> = 0.0001). Patients in the Omicron group did not show a significantly prolonged hospitalization time (<i>p</i> = 0.063) or a higher likelihood of death during hospitalization (<i>p</i> = 0.097). <b>Discussion:</b> In our study, despite the greater frailty of patients hospitalized during the Omicron period, the disease appeared less severe compared to previous waves, suggesting that the lower severity of the disease could be attributed to virological rather than population characteristics. These findings underscore the importance of prevention strategies for older people, as the administration of vaccination and early antiviral therapies in at-risk subjects.https://www.mdpi.com/2227-9059/13/7/1563agingomicron variantCOVID-19SARS-CoV-2 infection |
| spellingShingle | Pierantonio Grimaldi Mariantonietta Pisaturo Antonio Russo Salvatore Martini Francesca Ambrisi Filomena Milite Giovanni Di Caprio Fabio Giuliano Numis Ivan Gentile Vincenzo Sangiovanni Vincenzo Esposito Rossella Pacilio Giosuele Calabria Raffaella Pisapia Canio Carriero Alfonso Masullo Elio Manzillo Grazia Russo Roberto Parrella Sebastiano Leone Michele Gambardella Antonio Ponticiello Nicola Coppola The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort Biomedicines aging omicron variant COVID-19 SARS-CoV-2 infection |
| title | The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort |
| title_full | The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort |
| title_fullStr | The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort |
| title_full_unstemmed | The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort |
| title_short | The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort |
| title_sort | clinical impact of the omicron variant on octogenarian hospitalized covid 19 patients the results from covicamp cohort |
| topic | aging omicron variant COVID-19 SARS-CoV-2 infection |
| url | https://www.mdpi.com/2227-9059/13/7/1563 |
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