The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort

The Clinical Impact of the Omicron Variant on Octogenarian Hospitalized COVID-19 Patients: The Results from CoviCamp Cohort

<b>Introduction:</b> This study aims to investigate the clinical impact of Omicron Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection on the clinical presentation of Coronavirus Disease 2019 (COVID-19) in the very old (≥80 years old) population. <b>Methods:</...

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Main Authors: Pierantonio Grimaldi, Mariantonietta Pisaturo, Antonio Russo, Salvatore Martini, Francesca Ambrisi, Filomena Milite, Giovanni Di Caprio, Fabio Giuliano Numis, Ivan Gentile, Vincenzo Sangiovanni, Vincenzo Esposito, Rossella Pacilio, Giosuele Calabria, Raffaella Pisapia, Canio Carriero, Alfonso Masullo, Elio Manzillo, Grazia Russo, Roberto Parrella, Sebastiano Leone, Michele Gambardella, Antonio Ponticiello, Nicola Coppola
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomedicines
Subjects:
aging
omicron variant
COVID-19
SARS-CoV-2 infection
Online Access:https://www.mdpi.com/2227-9059/13/7/1563
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Summary:<b>Introduction:</b> This study aims to investigate the clinical impact of Omicron Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection on the clinical presentation of Coronavirus Disease 2019 (COVID-19) in the very old (≥80 years old) population. <b>Methods:</b> All patients aged 80 years or older, hospitalized from March 2020 to June 2023 with a SARS-CoV-2 infection in one of the 17 COVID-19 units in eight cities of Campania, southern Italy, were enrolled in a multicenter, observational, retrospective study. <b>Results:</b> 341 patients ≥ 80 years of age were included: 80 of them in the Omicron and 261 in the non-Omicron period. Patients admitted during the Omicron period were older (<i>p</i> = 0.0001) and more comorbid, showing more frequently arterial hypertension (<i>p</i> = 0.018), cardiovascular disease (<i>p</i> = 0.0001), chronic kidney disease (CKD) (<i>p</i> = 0.002), chronic obstructive pulmonary disease (COPD) (<i>p</i> = 0.001), and active cancer (<i>p</i> = 0.0001). Severe and critical outcomes were observed more often in the non-Omicron variant (<i>p</i> = 0.0001). Patients in the Omicron group did not show a significantly prolonged hospitalization time (<i>p</i> = 0.063) or a higher likelihood of death during hospitalization (<i>p</i> = 0.097). <b>Discussion:</b> In our study, despite the greater frailty of patients hospitalized during the Omicron period, the disease appeared less severe compared to previous waves, suggesting that the lower severity of the disease could be attributed to virological rather than population characteristics. These findings underscore the importance of prevention strategies for older people, as the administration of vaccination and early antiviral therapies in at-risk subjects.
ISSN:2227-9059

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