Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia
Background. Although the relationship between umbilical cord clamping time and various parameters such as hemoglobin (Hb) levels, iron deficiency, and risk of neonatal jaundice has previously been studied, to the best of our knowleadge there have been no studies investigating the relationship...
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| Language: | English |
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Hacettepe University Institute of Child Health
2020-10-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/510 |
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| author | Yüksel Yaşartekin S Ümit Sarıcı Murat Özcan Melis Akpınar Demet Altun Agah Akın Muhittin A Serdar Dilek Sarıcı |
| author_facet | Yüksel Yaşartekin S Ümit Sarıcı Murat Özcan Melis Akpınar Demet Altun Agah Akın Muhittin A Serdar Dilek Sarıcı |
| author_sort | Yüksel Yaşartekin |
| collection | DOAJ |
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Background. Although the relationship between umbilical cord clamping time and various parameters such as hemoglobin (Hb) levels, iron deficiency, and risk of neonatal jaundice has previously been studied, to the best of our knowleadge there have been no studies investigating the relationship between cord clamping time and the risk of significant hyperbilirubinemia. We aimed to investigate the relationship between the time of umbilical cord clamping and transcutaneous bilirubin (TcB) measurements made on various postnatal hours, Hb and serum total bilirubin (STB) levels measured on postnatal 4th day, and the risk of development of significant hyperbilirubinemia requiring phototherapy treatment.
Methods. Eligible newborns were divided into two groups on the basis of the time of cord clamping: those clamped late (60 seconds or more; Group I) and those clamped early (less than 60 seconds; Group II). Groups were compared with respect to the parameters of cord Hb, postnatal TcB measurements at 6th, 48th, 96th and 168th hours, and 96th hour Hb, STB and direct bilirubin levels.
Results. TcB levels at the 96th and 168th hour were significantly higher in Group I when compared to Group II (p < 0.001 and p < 0.001, respectively). The 96th hour STB level was significantly higher in Group I when compared to Group II (p < 0.001). The need of phototherapy requirement was higher in Group I when compared to Group II (p=0.001). Increase in cord blood Hb for each 1 gr/dl caused a 3.94-fold increased risk in the requirement of phototherapy treatment. Cord clamping time showed statistically significant positive correlations with both cord blood and 96th hour venous Hb levels, with both 96th hour and 168th hour TcB levels, and with 96th hour STB levels.
Conclusions. Newborns whose cords are clamped late should be followed up closely with respect to high postnatal bilirubin levels and other risks associated with significant hyperbilirubinemia requiring phototherapy treatment.
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| format | Article |
| id | doaj-art-6eb6a461a5ab4ec69c807fc09d202a66 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-6eb6a461a5ab4ec69c807fc09d202a662025-08-20T03:01:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212020-10-0162510.24953/turkjped.2020.05.006Investigation of the relationship between cord clamping time and risk of hyperbilirubinemiaYüksel Yaşartekin0S Ümit Sarıcı1Murat Özcan2Melis Akpınar3Demet Altun4Agah Akın5Muhittin A Serdar6Dilek Sarıcı7Division of Neonatology, Department of Pediatrics, Ufuk University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Ufuk University Faculty of Medicine, Ankara, Turkey.Department of Pediatrics, State Hospital, Haymana, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Ufuk University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Ufuk University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Ufuk University Faculty of Medicine, Ankara, Turkey.Department of Biochemistry, Acıbadem University Faculty of Medicine, Ankara, Turkey.Division of Neonatology, Department of Pediatrics, Kecioren Education and Research Hospital, Ankara, Turkey. Background. Although the relationship between umbilical cord clamping time and various parameters such as hemoglobin (Hb) levels, iron deficiency, and risk of neonatal jaundice has previously been studied, to the best of our knowleadge there have been no studies investigating the relationship between cord clamping time and the risk of significant hyperbilirubinemia. We aimed to investigate the relationship between the time of umbilical cord clamping and transcutaneous bilirubin (TcB) measurements made on various postnatal hours, Hb and serum total bilirubin (STB) levels measured on postnatal 4th day, and the risk of development of significant hyperbilirubinemia requiring phototherapy treatment. Methods. Eligible newborns were divided into two groups on the basis of the time of cord clamping: those clamped late (60 seconds or more; Group I) and those clamped early (less than 60 seconds; Group II). Groups were compared with respect to the parameters of cord Hb, postnatal TcB measurements at 6th, 48th, 96th and 168th hours, and 96th hour Hb, STB and direct bilirubin levels. Results. TcB levels at the 96th and 168th hour were significantly higher in Group I when compared to Group II (p < 0.001 and p < 0.001, respectively). The 96th hour STB level was significantly higher in Group I when compared to Group II (p < 0.001). The need of phototherapy requirement was higher in Group I when compared to Group II (p=0.001). Increase in cord blood Hb for each 1 gr/dl caused a 3.94-fold increased risk in the requirement of phototherapy treatment. Cord clamping time showed statistically significant positive correlations with both cord blood and 96th hour venous Hb levels, with both 96th hour and 168th hour TcB levels, and with 96th hour STB levels. Conclusions. Newborns whose cords are clamped late should be followed up closely with respect to high postnatal bilirubin levels and other risks associated with significant hyperbilirubinemia requiring phototherapy treatment. https://turkjpediatr.org/article/view/510hyperbilirubinemia; risk management; transcutaneous bilirubin measurements |
| spellingShingle | Yüksel Yaşartekin S Ümit Sarıcı Murat Özcan Melis Akpınar Demet Altun Agah Akın Muhittin A Serdar Dilek Sarıcı Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia The Turkish Journal of Pediatrics hyperbilirubinemia; risk management; transcutaneous bilirubin measurements |
| title | Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia |
| title_full | Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia |
| title_fullStr | Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia |
| title_full_unstemmed | Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia |
| title_short | Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia |
| title_sort | investigation of the relationship between cord clamping time and risk of hyperbilirubinemia |
| topic | hyperbilirubinemia; risk management; transcutaneous bilirubin measurements |
| url | https://turkjpediatr.org/article/view/510 |
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