Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review

Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review

BackgroundOxidized heme iron forms methemoglobin (MeHb), impairing the oxygen-binding capability of hemoglobin molecules. Nitric oxide (NO) obtained from glyceryl trinitrate (GTN) patches can cause MeHb formation during limb ischemia topical treatment. This case reports a preterm infant treated with...

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Bibliographic Details
Main Authors: Andrea Calandrino, Francesco Vinci, Marcella Battaglini, Samuele Caruggi, Chiara Andreato, Carolina Montobbio, Marianna Vannati, Diego Minghetti, Giorgia Brigati, Luca Antonio Ramenghi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pediatrics
Subjects:
neonates
prematurity
methemoglobinemia
nigroglycerine
ischemia
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1505233/full
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