When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells
Most of the human genome can be transcribed into RNAs, but only a minority of these regions produce protein-coding mRNAs whereas the remaining regions are transcribed into noncoding RNAs. Long noncoding RNAs (lncRNAs) were known for their influential regulatory roles in multiple biological processes...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3250624 |
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| _version_ | 1832556191089164288 |
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| author | Fuquan Chen Jiaojiao Ji Jian Shen Xinyi Lu |
| author_facet | Fuquan Chen Jiaojiao Ji Jian Shen Xinyi Lu |
| author_sort | Fuquan Chen |
| collection | DOAJ |
| description | Most of the human genome can be transcribed into RNAs, but only a minority of these regions produce protein-coding mRNAs whereas the remaining regions are transcribed into noncoding RNAs. Long noncoding RNAs (lncRNAs) were known for their influential regulatory roles in multiple biological processes such as imprinting, dosage compensation, transcriptional regulation, and splicing. The physiological functions of protein-coding genes have been extensively characterized through genome editing in pluripotent stem cells (PSCs) in the past 30 years; however, the study of lncRNAs with genome editing technologies only came into attentions in recent years. Here, we summarize recent advancements in dissecting the roles of lncRNAs with genome editing technologies in PSCs and highlight potential genome editing tools useful for examining the functions of lncRNAs in PSCs. |
| format | Article |
| id | doaj-art-6ea7fae912584d48907bfa3a7238b362 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6ea7fae912584d48907bfa3a7238b3622025-02-03T05:46:11ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/32506243250624When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem CellsFuquan Chen0Jiaojiao Ji1Jian Shen2Xinyi Lu3State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300371, ChinaState Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300371, ChinaState Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300371, ChinaState Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300371, ChinaMost of the human genome can be transcribed into RNAs, but only a minority of these regions produce protein-coding mRNAs whereas the remaining regions are transcribed into noncoding RNAs. Long noncoding RNAs (lncRNAs) were known for their influential regulatory roles in multiple biological processes such as imprinting, dosage compensation, transcriptional regulation, and splicing. The physiological functions of protein-coding genes have been extensively characterized through genome editing in pluripotent stem cells (PSCs) in the past 30 years; however, the study of lncRNAs with genome editing technologies only came into attentions in recent years. Here, we summarize recent advancements in dissecting the roles of lncRNAs with genome editing technologies in PSCs and highlight potential genome editing tools useful for examining the functions of lncRNAs in PSCs.http://dx.doi.org/10.1155/2017/3250624 |
| spellingShingle | Fuquan Chen Jiaojiao Ji Jian Shen Xinyi Lu When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells Stem Cells International |
| title | When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells |
| title_full | When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells |
| title_fullStr | When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells |
| title_full_unstemmed | When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells |
| title_short | When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells |
| title_sort | when long noncoding rnas meet genome editing in pluripotent stem cells |
| url | http://dx.doi.org/10.1155/2017/3250624 |
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