Predicting high confidence ctDNA somatic variants with ensemble machine learning models

Abstract Circulating tumour DNA (ctDNA) is a minimally invasive cancer biomarker that can be used to inform treatment of cancer patients. The utility of ctDNA as a cancer biomarker depends on the ability to accurately detect somatic variants associated with cancer. Accurate somatic variant detection...

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Bibliographic Details
Main Authors: Rugare Maruzani, Liam Brierley, Andrea Jorgensen, Anna Fowler
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-01326-2
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