Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit
This work was undertaken to elucidate some aspects of the epidemiology of Pneumocystis pneumonia (PP). We studied 42 mechanically ventilated, human immunodeficiency virus (HIV)-negative, severely ill neonates treated at an intensive care unit. The study group included 40 premature neonates an...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2007-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2529 |
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| author | Agnieszka Kordek Lidia Kołodziejczyk Małgorzata Adamska Bogumiła Skotarczak Beata Loniewska Beata Pawlus Wanda Kuźna-Grygiel Jacek Rudnicki Ryszard Czajka |
| author_facet | Agnieszka Kordek Lidia Kołodziejczyk Małgorzata Adamska Bogumiła Skotarczak Beata Loniewska Beata Pawlus Wanda Kuźna-Grygiel Jacek Rudnicki Ryszard Czajka |
| author_sort | Agnieszka Kordek |
| collection | DOAJ |
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This work was undertaken to elucidate some aspects of the epidemiology of Pneumocystis pneumonia (PP). We studied 42 mechanically ventilated, human immunodeficiency virus (HIV)-negative, severely ill neonates treated at an intensive care unit. The study group included 40 premature neonates and two mature neonates with lethal congenital defects. Progressive respiratory dysfunction in PP necessitated mechanical ventilation. Infection was usually noticeable on the 22nd day of life or after 12 days of ventilation. The usual manifestations included apnea, pallor, copious frothy sputum, seizures, and feeding difficulties. The diagnosis was established by detecting Pneumocystis jiroveci cysts in bronchial lavage fluid specimens (88.1% sensitivity). PP was managed with cotrimoxazole and pentamidine combination therapy administered over 14 days. No clinical improvement was noted in four neonates and three of them died during therapy. Prematurity and protracted mechanical ventilation are two risk factors for P. jiroveci infection in severely ill neonates in an intensive care unit.
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| format | Article |
| id | doaj-art-6ea2e3b33c524d388c25192f2aa8d888 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2007-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-6ea2e3b33c524d388c25192f2aa8d8882025-08-20T02:01:57ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212007-04-01492Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unitAgnieszka Kordek0Lidia KołodziejczykMałgorzata AdamskaBogumiła SkotarczakBeata LoniewskaBeata PawlusWanda Kuźna-GrygielJacek RudnickiRyszard CzajkaClinic of Obstetrics and Perinatology, Pomeranian Medical University, Szczecin, Poland. This work was undertaken to elucidate some aspects of the epidemiology of Pneumocystis pneumonia (PP). We studied 42 mechanically ventilated, human immunodeficiency virus (HIV)-negative, severely ill neonates treated at an intensive care unit. The study group included 40 premature neonates and two mature neonates with lethal congenital defects. Progressive respiratory dysfunction in PP necessitated mechanical ventilation. Infection was usually noticeable on the 22nd day of life or after 12 days of ventilation. The usual manifestations included apnea, pallor, copious frothy sputum, seizures, and feeding difficulties. The diagnosis was established by detecting Pneumocystis jiroveci cysts in bronchial lavage fluid specimens (88.1% sensitivity). PP was managed with cotrimoxazole and pentamidine combination therapy administered over 14 days. No clinical improvement was noted in four neonates and three of them died during therapy. Prematurity and protracted mechanical ventilation are two risk factors for P. jiroveci infection in severely ill neonates in an intensive care unit. https://turkjpediatr.org/article/view/2529 |
| spellingShingle | Agnieszka Kordek Lidia Kołodziejczyk Małgorzata Adamska Bogumiła Skotarczak Beata Loniewska Beata Pawlus Wanda Kuźna-Grygiel Jacek Rudnicki Ryszard Czajka Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit The Turkish Journal of Pediatrics |
| title | Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit |
| title_full | Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit |
| title_fullStr | Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit |
| title_full_unstemmed | Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit |
| title_short | Prematurity and protracted mechanical ventilation as risk factors for Pneumocystis jiroveci infection in HIV-negative neonates in an intensive care unit |
| title_sort | prematurity and protracted mechanical ventilation as risk factors for pneumocystis jiroveci infection in hiv negative neonates in an intensive care unit |
| url | https://turkjpediatr.org/article/view/2529 |
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