Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders
Abstract Inflammation is a complex, tightly regulated process involving biochemical and cellular reactions to harmful stimuli. Often termed “the internal fire”, it is crucial for protecting the body and facilitating tissue healing. While inflammation is essential for survival, chronic inflammation c...
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| Format: | Article |
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BMC
2025-05-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02649-6 |
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| author | Mohamed J. Saadh Faris Anad Muhammad Rafid Jihad Albadr Gaurav Sanghvi Suhas Ballal Piyus Kumar Pathak Lakshay Bareja Zafar Aminov Waam Mohammed Taher Mariem Alwan Mahmood Jasem Jawad Ali M. Ali Al-Nuaimi |
| author_facet | Mohamed J. Saadh Faris Anad Muhammad Rafid Jihad Albadr Gaurav Sanghvi Suhas Ballal Piyus Kumar Pathak Lakshay Bareja Zafar Aminov Waam Mohammed Taher Mariem Alwan Mahmood Jasem Jawad Ali M. Ali Al-Nuaimi |
| author_sort | Mohamed J. Saadh |
| collection | DOAJ |
| description | Abstract Inflammation is a complex, tightly regulated process involving biochemical and cellular reactions to harmful stimuli. Often termed “the internal fire”, it is crucial for protecting the body and facilitating tissue healing. While inflammation is essential for survival, chronic inflammation can be detrimental, leading to tissue damage and reduced survival. The innate immune system triggers inflammation, closely linked to the development of heart diseases, with significant consequences for individuals. Inflammation in arterial walls or the body substantially contributes to atherosclerotic disease progression, affecting the cardiovascular system. Altered lipoproteins increase the risk of excessive blood clotting, a hallmark of atherosclerotic cardiovascular disease and its complications. Integrating inflammatory biomarkers with established risk assessment techniques can enhance our ability to identify at-risk individuals, assess their risk severity, and recommend appropriate CVD prevention strategies. Exosomes, a type of extracellular vesicle, are released by various cells and mediate cell communication locally and systemically. In the past decade, exosomes have been increasingly studied for their vital roles in health maintenance and disease processes. They can transport substances like non-coding RNAs, lipids, and proteins between cells, influencing immune responses and inflammation to elicit harmful or healing effects. This study focuses on the critical role of inflammation in heart disease progression and how non-coding RNAs in exosomes modulate the inflammatory process, either exacerbating or alleviating inflammation-related damage in the cardiovascular system. |
| format | Article |
| id | doaj-art-6e95c5060ab14ece8ffddecb9aacad1f |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-6e95c5060ab14ece8ffddecb9aacad1f2025-08-20T01:52:29ZengBMCEuropean Journal of Medical Research2047-783X2025-05-0130112010.1186/s40001-025-02649-6Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disordersMohamed J. Saadh0Faris Anad Muhammad1Rafid Jihad Albadr2Gaurav Sanghvi3Suhas Ballal4Piyus Kumar Pathak5Lakshay Bareja6Zafar Aminov7Waam Mohammed Taher8Mariem Alwan9Mahmood Jasem Jawad10Ali M. Ali Al-Nuaimi11Faculty of Pharmacy, Middle East UniversityCollege of Pharmacy, Alnoor UniversityAhl Al Bayt UniversityMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi UniversityDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University)Department of Applied Sciences-Chemistry, NIMS Institute of Engineering & Technology, NIMS University RajasthanCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara UniversityDepartment of Public Health and Healthcare Management, Samarkand State Medical UniversityCollege of Nursing, National University of Science and TechnologyPharmacy College, Al-Farahidi UniversityDepartment of Pharmacy, Al-Zahrawi University CollegeGilgamesh Ahliya UniversityAbstract Inflammation is a complex, tightly regulated process involving biochemical and cellular reactions to harmful stimuli. Often termed “the internal fire”, it is crucial for protecting the body and facilitating tissue healing. While inflammation is essential for survival, chronic inflammation can be detrimental, leading to tissue damage and reduced survival. The innate immune system triggers inflammation, closely linked to the development of heart diseases, with significant consequences for individuals. Inflammation in arterial walls or the body substantially contributes to atherosclerotic disease progression, affecting the cardiovascular system. Altered lipoproteins increase the risk of excessive blood clotting, a hallmark of atherosclerotic cardiovascular disease and its complications. Integrating inflammatory biomarkers with established risk assessment techniques can enhance our ability to identify at-risk individuals, assess their risk severity, and recommend appropriate CVD prevention strategies. Exosomes, a type of extracellular vesicle, are released by various cells and mediate cell communication locally and systemically. In the past decade, exosomes have been increasingly studied for their vital roles in health maintenance and disease processes. They can transport substances like non-coding RNAs, lipids, and proteins between cells, influencing immune responses and inflammation to elicit harmful or healing effects. This study focuses on the critical role of inflammation in heart disease progression and how non-coding RNAs in exosomes modulate the inflammatory process, either exacerbating or alleviating inflammation-related damage in the cardiovascular system.https://doi.org/10.1186/s40001-025-02649-6Cardiovascular diseaseInflammationExosomeMicroRNALncRNA |
| spellingShingle | Mohamed J. Saadh Faris Anad Muhammad Rafid Jihad Albadr Gaurav Sanghvi Suhas Ballal Piyus Kumar Pathak Lakshay Bareja Zafar Aminov Waam Mohammed Taher Mariem Alwan Mahmood Jasem Jawad Ali M. Ali Al-Nuaimi Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders European Journal of Medical Research Cardiovascular disease Inflammation Exosome MicroRNA LncRNA |
| title | Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders |
| title_full | Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders |
| title_fullStr | Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders |
| title_full_unstemmed | Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders |
| title_short | Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders |
| title_sort | exosomal non coding rnas key regulators of inflammation related cardiovascular disorders |
| topic | Cardiovascular disease Inflammation Exosome MicroRNA LncRNA |
| url | https://doi.org/10.1186/s40001-025-02649-6 |
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