Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair
Regenerative medicine endeavors to restore damaged tissues and organs utilizing biological approaches. Utilizing biomaterials to target and regulate the pathophysiological processes of injured tissues stands as a crucial method in propelling this field forward. The Extracellular Vesicles-in-Hydrogel...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-02-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004626 |
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| author | Lubin Liu Wei Liu Zeyu Han Yansheng Shan Yutong Xie Jialu Wang Hongzhao Qi Quanchen Xu |
| author_facet | Lubin Liu Wei Liu Zeyu Han Yansheng Shan Yutong Xie Jialu Wang Hongzhao Qi Quanchen Xu |
| author_sort | Lubin Liu |
| collection | DOAJ |
| description | Regenerative medicine endeavors to restore damaged tissues and organs utilizing biological approaches. Utilizing biomaterials to target and regulate the pathophysiological processes of injured tissues stands as a crucial method in propelling this field forward. The Extracellular Vesicles-in-Hydrogel (EViH) system amalgamates the advantages of extracellular vesicles (EVs) and hydrogels, rendering it a prominent biomaterial in regenerative medicine with substantial potential for clinical translation. This review elucidates the development and benefits of the EViH system in tissue regeneration, emphasizing the interaction and impact of EVs and hydrogels. Furthermore, it succinctly outlines the pathophysiological characteristics of various types of tissue injuries such as wounds, bone and cartilage injuries, cardiovascular diseases, nerve injuries, as well as liver and kidney injuries, underscoring how EViH systems target these processes to address related tissue damage. Lastly, it explores the challenges and prospects in further advancing EViH-based tissue regeneration, aiming to impart a comprehensive understanding of EViH. The objective is to furnish a thorough overview of EViH in enhancing regenerative medicine applications and to inspire researchers to devise innovative tissue engineering materials for regenerative medicine. |
| format | Article |
| id | doaj-art-6e909b2e79e44b5ea35d446a26d7e4d1 |
| institution | DOAJ |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-6e909b2e79e44b5ea35d446a26d7e4d12025-08-20T02:39:30ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-02-014428331810.1016/j.bioactmat.2024.10.017Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repairLubin Liu0Wei Liu1Zeyu Han2Yansheng Shan3Yutong Xie4Jialu Wang5Hongzhao Qi6Quanchen Xu7Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; School of Stomatology, Qingdao University, Qingdao, 266023, ChinaDepartment of Emergency Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, 266003, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; School of Stomatology, Qingdao University, Qingdao, 266023, ChinaSchool of Stomatology, Qingdao University, Qingdao, 266023, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; School of Stomatology, Qingdao University, Qingdao, 266023, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; School of Stomatology, Qingdao University, Qingdao, 266023, ChinaInstitute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, 266021, China; Corresponding author.Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; School of Stomatology, Qingdao University, Qingdao, 266023, China; Corresponding author. Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.Regenerative medicine endeavors to restore damaged tissues and organs utilizing biological approaches. Utilizing biomaterials to target and regulate the pathophysiological processes of injured tissues stands as a crucial method in propelling this field forward. The Extracellular Vesicles-in-Hydrogel (EViH) system amalgamates the advantages of extracellular vesicles (EVs) and hydrogels, rendering it a prominent biomaterial in regenerative medicine with substantial potential for clinical translation. This review elucidates the development and benefits of the EViH system in tissue regeneration, emphasizing the interaction and impact of EVs and hydrogels. Furthermore, it succinctly outlines the pathophysiological characteristics of various types of tissue injuries such as wounds, bone and cartilage injuries, cardiovascular diseases, nerve injuries, as well as liver and kidney injuries, underscoring how EViH systems target these processes to address related tissue damage. Lastly, it explores the challenges and prospects in further advancing EViH-based tissue regeneration, aiming to impart a comprehensive understanding of EViH. The objective is to furnish a thorough overview of EViH in enhancing regenerative medicine applications and to inspire researchers to devise innovative tissue engineering materials for regenerative medicine.http://www.sciencedirect.com/science/article/pii/S2452199X24004626Extracellular vesiclesHydrogelRegeneration medicineTissue engineeringTissue repair |
| spellingShingle | Lubin Liu Wei Liu Zeyu Han Yansheng Shan Yutong Xie Jialu Wang Hongzhao Qi Quanchen Xu Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair Bioactive Materials Extracellular vesicles Hydrogel Regeneration medicine Tissue engineering Tissue repair |
| title | Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair |
| title_full | Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair |
| title_fullStr | Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair |
| title_full_unstemmed | Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair |
| title_short | Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair |
| title_sort | extracellular vesicles in hydrogel evih targeting pathophysiology for tissue repair |
| topic | Extracellular vesicles Hydrogel Regeneration medicine Tissue engineering Tissue repair |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004626 |
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