Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study.
Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant t...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142425&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850125312776470528 |
|---|---|
| author | Helen R Stagg James Brown Elmira Ibraim Vija Riekstiņa Piret Viiklepp Andra Cīrule Horia Cocei Manfred Danilovitš Gunta Dravniece Charlotte Jackson Peter J White |
| author_facet | Helen R Stagg James Brown Elmira Ibraim Vija Riekstiņa Piret Viiklepp Andra Cīrule Horia Cocei Manfred Danilovitš Gunta Dravniece Charlotte Jackson Peter J White |
| author_sort | Helen R Stagg |
| collection | DOAJ |
| description | Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate drug susceptibility testing and drug susceptibility testing data are vital to inform the development of comprehensive, flexible, multidrug resistant tuberculosis guidance. |
| format | Article |
| id | doaj-art-6e7f0a930bca4524b8bd86b70da422e1 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6e7f0a930bca4524b8bd86b70da422e12025-08-20T02:34:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014242510.1371/journal.pone.0142425Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study.Helen R StaggJames BrownElmira IbraimVija RiekstiņaPiret ViikleppAndra CīruleHoria CoceiManfred DanilovitšGunta DravnieceCharlotte JacksonPeter J WhiteGlobally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate drug susceptibility testing and drug susceptibility testing data are vital to inform the development of comprehensive, flexible, multidrug resistant tuberculosis guidance.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142425&type=printable |
| spellingShingle | Helen R Stagg James Brown Elmira Ibraim Vija Riekstiņa Piret Viiklepp Andra Cīrule Horia Cocei Manfred Danilovitš Gunta Dravniece Charlotte Jackson Peter J White Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study. PLoS ONE |
| title | Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study. |
| title_full | Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study. |
| title_fullStr | Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study. |
| title_full_unstemmed | Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study. |
| title_short | Drug Susceptibility Patterns in MDR-TB Patients: Challenges for Future Regimen Design. A Cross-Sectional Study. |
| title_sort | drug susceptibility patterns in mdr tb patients challenges for future regimen design a cross sectional study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142425&type=printable |
| work_keys_str_mv | AT helenrstagg drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT jamesbrown drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT elmiraibraim drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT vijariekstina drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT piretviiklepp drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT andracirule drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT horiacocei drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT manfreddanilovits drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT guntadravniece drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT charlottejackson drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy AT peterjwhite drugsusceptibilitypatternsinmdrtbpatientschallengesforfutureregimendesignacrosssectionalstudy |