Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors

Mycobacterium avium complex (MAC) infections rarely affect the pleura, accounting for 5–15% of pulmonary MAC. We report a case of MAC pleural effusion in an otherwise immunocompetent young patient. A 37-year-old healthy female with no past medical history was admitted to the hospital with two weeks...

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Main Authors: Ravi P. Manglani, Misbahuddin Khaja, Karen Hennessey, Omonuwa Kennedy
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Case Reports in Pulmonology
Online Access:http://dx.doi.org/10.1155/2015/760614
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author Ravi P. Manglani
Misbahuddin Khaja
Karen Hennessey
Omonuwa Kennedy
author_facet Ravi P. Manglani
Misbahuddin Khaja
Karen Hennessey
Omonuwa Kennedy
author_sort Ravi P. Manglani
collection DOAJ
description Mycobacterium avium complex (MAC) infections rarely affect the pleura, accounting for 5–15% of pulmonary MAC. We report a case of MAC pleural effusion in an otherwise immunocompetent young patient. A 37-year-old healthy female with no past medical history was admitted to the hospital with two weeks of right sided pleuritic chest pain, productive cough, and fever. She was febrile, tachycardic, and tachypneic with signs of right sided pleural effusion which were confirmed by chest X-ray and chest CT. Thoracentesis revealed lymphocytic predominant exudative fluid. The patient underwent pleural biopsy, bronchoscopy with bronchoalveolar lavage, and video assisted thoracoscopic surgery (VATS), all of which failed to identify the causative organism. Six weeks later, MAC was identified in the pleural fluid and pleural biopsy by DNA hybridization and culture. The patient was started on clarithromycin, ethambutol, and rifampin. After six months of treatment, she was asymptomatic with complete radiological resolution of the effusion. The presence of lymphocytic effusion should raise the suspicion for both tuberculous and nontuberculous mycobacterial disease. Pleural biopsy must be considered to make the diagnosis. Clinicians must maintain a high index of suspicion of MAC infection in an otherwise immunocompetent patient presenting with a unilateral lymphocytic exudative effusion.
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spelling doaj-art-6e774fcd8072477ca6a153386f4831ea2025-02-03T06:12:15ZengWileyCase Reports in Pulmonology2090-68462090-68542015-01-01201510.1155/2015/760614760614Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk FactorsRavi P. Manglani0Misbahuddin Khaja1Karen Hennessey2Omonuwa Kennedy3Lincoln Medical and Mental Health Center, Department of Internal Medicine, New York, NY 10451, USALincoln Medical and Mental Health Center, Department of Internal Medicine, New York, NY 10451, USALincoln Medical and Mental Health Center, Department of Internal Medicine, New York, NY 10451, USALincoln Medical and Mental Health Center, Department of Internal Medicine, New York, NY 10451, USAMycobacterium avium complex (MAC) infections rarely affect the pleura, accounting for 5–15% of pulmonary MAC. We report a case of MAC pleural effusion in an otherwise immunocompetent young patient. A 37-year-old healthy female with no past medical history was admitted to the hospital with two weeks of right sided pleuritic chest pain, productive cough, and fever. She was febrile, tachycardic, and tachypneic with signs of right sided pleural effusion which were confirmed by chest X-ray and chest CT. Thoracentesis revealed lymphocytic predominant exudative fluid. The patient underwent pleural biopsy, bronchoscopy with bronchoalveolar lavage, and video assisted thoracoscopic surgery (VATS), all of which failed to identify the causative organism. Six weeks later, MAC was identified in the pleural fluid and pleural biopsy by DNA hybridization and culture. The patient was started on clarithromycin, ethambutol, and rifampin. After six months of treatment, she was asymptomatic with complete radiological resolution of the effusion. The presence of lymphocytic effusion should raise the suspicion for both tuberculous and nontuberculous mycobacterial disease. Pleural biopsy must be considered to make the diagnosis. Clinicians must maintain a high index of suspicion of MAC infection in an otherwise immunocompetent patient presenting with a unilateral lymphocytic exudative effusion.http://dx.doi.org/10.1155/2015/760614
spellingShingle Ravi P. Manglani
Misbahuddin Khaja
Karen Hennessey
Omonuwa Kennedy
Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors
Case Reports in Pulmonology
title Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors
title_full Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors
title_fullStr Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors
title_full_unstemmed Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors
title_short Pleural Mycobacterium Avium Complex Infection in an Immunocompetent Female with No Risk Factors
title_sort pleural mycobacterium avium complex infection in an immunocompetent female with no risk factors
url http://dx.doi.org/10.1155/2015/760614
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AT karenhennessey pleuralmycobacteriumaviumcomplexinfectioninanimmunocompetentfemalewithnoriskfactors
AT omonuwakennedy pleuralmycobacteriumaviumcomplexinfectioninanimmunocompetentfemalewithnoriskfactors