Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation

Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation

IntroductionThe potential for therapeutic strategies that promote angiogenesis and suppress neuroinflammation to ameliorate cognitive decline induced by chronic cerebral hypoperfusion (CCH) has led to their recognition as promising therapeutic targets for vascular dementia (VD). The SIRT1-mediated N...

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Bibliographic Details
Main Authors: Meixi Li, Jiaxi Song, Xiaoli Niu, Feng Mo, Xiaohua Xie, Xiuqin Li, Yu Yin, Tianjun Wang, Xiujuan Song, Jingze Liu, Peiyuan Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
vascular dementia (VD)
baicalein
angiogenesis
neuroinflammation
SIRT1-mediated Notch1 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1521353/full
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