The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women
Abstract Objectives To determine the association between hypomagnesemia and dynapenia in older women with different nutritional status. Methods This cross-sectional study included older women who attended one outpatient geriatric clinic. Undernutrition was defined according to the Mini Nutritional A...
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BMC
2025-02-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-05742-x |
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| author | Ozcan Uzun Cihan Heybeli Lee Smith Nicola Veronese Masoud Rahmati Andre Hajek Pinar Soysal |
| author_facet | Ozcan Uzun Cihan Heybeli Lee Smith Nicola Veronese Masoud Rahmati Andre Hajek Pinar Soysal |
| author_sort | Ozcan Uzun |
| collection | DOAJ |
| description | Abstract Objectives To determine the association between hypomagnesemia and dynapenia in older women with different nutritional status. Methods This cross-sectional study included older women who attended one outpatient geriatric clinic. Undernutrition was defined according to the Mini Nutritional Assessment score (MNA) (< 23,5), and handgrip strength of < 16 kg on dynamometer was defined as dynapenia. The association between hypomagnesemia (serum magnesium < 1.7 mg/dL) and dynapenia was determined by logistic regression analysis. Results Among the 933 older women (mean age 81 ± 8), the prevalences of undernutrition and hypomagnesemia were 61% and 15%, respectively. The risk of hypomagnesemia increased with each step of decline in nutritional status, and undernutrition was associated with hypomagnesemia (OR 1.64, 95% CI 1.11–2.43, p = 0.013) In the entire cohort, hypomagnesemia was associated with dynapenia (OR 2.01, 95% CI 1.35-3.00, p = 0.001). In well-nourished patients, hypomagnesemia was not associated with dynapenia, even when unadjusted. However, in the undernourished group, hypomagnesemia was associated with dynapenia after adjusting for age, diabetes mellitus, hypertension, coronary heart disease, Barthel and Lawton scores, polypharmacy, glomerular filtration rate, serum albumin, hemoglobin, and MNA score (OR 2.95, 95% CI 1.04–8.32, p = 0.040). The coexistence of hypomagnesemia and undernutrition (versus neither of them) was significantly associated with dynapenia (OR 4.44, 95% CI 2.67–7.41, p < 0.001). Conclusion The prevalence of hypomagnesemia increases with worsening nutritional status. Hypomagnesemia is associated with dynapenia in older women who are undernourished, even after adjusting for nutritional status, but not in those who are well nourished. The coexistence of undernutrition and hypomagnesemia increase the risk of dynapenia substantially. |
| format | Article |
| id | doaj-art-6e6a1b11a3924009b8ed586ff65adb6f |
| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj-art-6e6a1b11a3924009b8ed586ff65adb6f2025-02-09T12:53:29ZengBMCBMC Geriatrics1471-23182025-02-012511810.1186/s12877-025-05742-xThe impact of undernutrition on the association between hypomagnesemia and dynapenia in older womenOzcan Uzun0Cihan Heybeli1Lee Smith2Nicola Veronese3Masoud Rahmati4Andre Hajek5Pinar Soysal6Yalova Education and Research Hospital, Division of NephrologyDivision of Nephrology, Dokuz Eylul University HospitalCenter for Health Performance and Wellbeing, Anglia Ruskin UniversityGeriatric Unit, Department of Medicine, University of PalermoCEReSS-Health Service Research and Quality of Life Center, Aix-Marseille UniversityDepartment of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg Center for Health EconomicsDepartment of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif UniversityAbstract Objectives To determine the association between hypomagnesemia and dynapenia in older women with different nutritional status. Methods This cross-sectional study included older women who attended one outpatient geriatric clinic. Undernutrition was defined according to the Mini Nutritional Assessment score (MNA) (< 23,5), and handgrip strength of < 16 kg on dynamometer was defined as dynapenia. The association between hypomagnesemia (serum magnesium < 1.7 mg/dL) and dynapenia was determined by logistic regression analysis. Results Among the 933 older women (mean age 81 ± 8), the prevalences of undernutrition and hypomagnesemia were 61% and 15%, respectively. The risk of hypomagnesemia increased with each step of decline in nutritional status, and undernutrition was associated with hypomagnesemia (OR 1.64, 95% CI 1.11–2.43, p = 0.013) In the entire cohort, hypomagnesemia was associated with dynapenia (OR 2.01, 95% CI 1.35-3.00, p = 0.001). In well-nourished patients, hypomagnesemia was not associated with dynapenia, even when unadjusted. However, in the undernourished group, hypomagnesemia was associated with dynapenia after adjusting for age, diabetes mellitus, hypertension, coronary heart disease, Barthel and Lawton scores, polypharmacy, glomerular filtration rate, serum albumin, hemoglobin, and MNA score (OR 2.95, 95% CI 1.04–8.32, p = 0.040). The coexistence of hypomagnesemia and undernutrition (versus neither of them) was significantly associated with dynapenia (OR 4.44, 95% CI 2.67–7.41, p < 0.001). Conclusion The prevalence of hypomagnesemia increases with worsening nutritional status. Hypomagnesemia is associated with dynapenia in older women who are undernourished, even after adjusting for nutritional status, but not in those who are well nourished. The coexistence of undernutrition and hypomagnesemia increase the risk of dynapenia substantially.https://doi.org/10.1186/s12877-025-05742-xAgedHypomagnesemiaMagnesiumMalnutritionSarcopenia |
| spellingShingle | Ozcan Uzun Cihan Heybeli Lee Smith Nicola Veronese Masoud Rahmati Andre Hajek Pinar Soysal The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women BMC Geriatrics Aged Hypomagnesemia Magnesium Malnutrition Sarcopenia |
| title | The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women |
| title_full | The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women |
| title_fullStr | The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women |
| title_full_unstemmed | The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women |
| title_short | The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women |
| title_sort | impact of undernutrition on the association between hypomagnesemia and dynapenia in older women |
| topic | Aged Hypomagnesemia Magnesium Malnutrition Sarcopenia |
| url | https://doi.org/10.1186/s12877-025-05742-x |
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