Functional organotypic human lymph node model with native immune cells benefits from fibroblastic reticular cell enrichment

Functional organotypic human lymph node model with native immune cells benefits from fibroblastic reticular cell enrichment

Abstract Lymphoid organ function depends on fibroblastic reticular cells (FRCs), the non-hematopoietic mesenchymal stromal cells that crucially support immune activity in human lymph nodes (LNs). The in vitro study of human immunology requires physiological LN models, yet the inclusion of FRCs in cu...

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Bibliographic Details
Main Authors: Andrew I. Morrison, Jesse E. Kuipers, Henk P. Roest, Luc J. W. van der Laan, Charlotte M. de Winde, Jasper J. Koning, Susan Gibbs, Reina E. Mebius
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-95031-9
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