Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities
Abstract Objective This study aimed to analyze the trends and epidemiological characteristics of pancreatic cancer (PC) mortality in China from 2004 to 2021, focusing on gender, age, and regional disparities. The goal was to provide a comprehensive understanding of PC mortality and identify key risk...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13863-0 |
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| author | Rui He Zhengnan Shen Qiuping Chen Haiyang Hu Xin Ding Zhenglong Zheng Quansheng Feng Baixue Li |
| author_facet | Rui He Zhengnan Shen Qiuping Chen Haiyang Hu Xin Ding Zhenglong Zheng Quansheng Feng Baixue Li |
| author_sort | Rui He |
| collection | DOAJ |
| description | Abstract Objective This study aimed to analyze the trends and epidemiological characteristics of pancreatic cancer (PC) mortality in China from 2004 to 2021, focusing on gender, age, and regional disparities. The goal was to provide a comprehensive understanding of PC mortality and identify key risk factors to support future prevention and control strategies. Methods Using data from the national Disease Surveillance Point (DSP) system, which covers a large and representative sample of the Chinese population, the study examined pancreatic cancer mortality trends across different age groups, sexes, and regions. Statistical analyses, including the independent-sample t-test and age-period-cohort (APC) model, were employed to assess mortality differences and annual percentage changes from 2004 to 2021. Results The study recorded a significant increase in pancreatic cancer mortality, particularly among males and older adults. Mortality was consistently higher in urban areas, but the growth rate in rural areas surpassed that of urban areas. Regional disparities were also observed, with the eastern region showing the highest mortality rates but slower increases compared to the central and western regions. Key risk factors, including aging, diabetes, smoking, and chronic pancreatitis, were identified, with gender-specific differences linked to lifestyle factors such as smoking and alcohol consumption. Conclusion Pancreatic cancer mortality in China has shown significant increases over the past 18 years, especially among males, older adults, and rural populations. The findings highlight the urgent need for targeted public health interventions to address gender- and age-specific risks, as well as healthcare access inequalities in less developed regions. Future research should focus on gathering more granular, individual-level data to better understand the complex interplay of risk factors and inform more effective prevention and treatment strategies. |
| format | Article |
| id | doaj-art-6e634473ed1c411ca38d3ea3fb19b241 |
| institution | OA Journals |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-6e634473ed1c411ca38d3ea3fb19b2412025-08-20T02:33:31ZengBMCBMC Cancer1471-24072025-05-0125111410.1186/s12885-025-13863-0Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparitiesRui He0Zhengnan Shen1Qiuping Chen2Haiyang Hu3Xin Ding4Zhenglong Zheng5Quansheng Feng6Baixue Li7Chengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineAbstract Objective This study aimed to analyze the trends and epidemiological characteristics of pancreatic cancer (PC) mortality in China from 2004 to 2021, focusing on gender, age, and regional disparities. The goal was to provide a comprehensive understanding of PC mortality and identify key risk factors to support future prevention and control strategies. Methods Using data from the national Disease Surveillance Point (DSP) system, which covers a large and representative sample of the Chinese population, the study examined pancreatic cancer mortality trends across different age groups, sexes, and regions. Statistical analyses, including the independent-sample t-test and age-period-cohort (APC) model, were employed to assess mortality differences and annual percentage changes from 2004 to 2021. Results The study recorded a significant increase in pancreatic cancer mortality, particularly among males and older adults. Mortality was consistently higher in urban areas, but the growth rate in rural areas surpassed that of urban areas. Regional disparities were also observed, with the eastern region showing the highest mortality rates but slower increases compared to the central and western regions. Key risk factors, including aging, diabetes, smoking, and chronic pancreatitis, were identified, with gender-specific differences linked to lifestyle factors such as smoking and alcohol consumption. Conclusion Pancreatic cancer mortality in China has shown significant increases over the past 18 years, especially among males, older adults, and rural populations. The findings highlight the urgent need for targeted public health interventions to address gender- and age-specific risks, as well as healthcare access inequalities in less developed regions. Future research should focus on gathering more granular, individual-level data to better understand the complex interplay of risk factors and inform more effective prevention and treatment strategies.https://doi.org/10.1186/s12885-025-13863-0Pancreatic cancerEpidemiologyMortality trendsRisk factorsChina |
| spellingShingle | Rui He Zhengnan Shen Qiuping Chen Haiyang Hu Xin Ding Zhenglong Zheng Quansheng Feng Baixue Li Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities BMC Cancer Pancreatic cancer Epidemiology Mortality trends Risk factors China |
| title | Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities |
| title_full | Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities |
| title_fullStr | Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities |
| title_full_unstemmed | Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities |
| title_short | Pancreatic cancer mortality in China from 2004 to 2021: an in-depth analysis of age, gender, and regional disparities |
| title_sort | pancreatic cancer mortality in china from 2004 to 2021 an in depth analysis of age gender and regional disparities |
| topic | Pancreatic cancer Epidemiology Mortality trends Risk factors China |
| url | https://doi.org/10.1186/s12885-025-13863-0 |
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