Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System
Classical inflammation is a well-characterized secondary response to many acute disorders of the central nervous system. However, in recent years, the role of neurogenic inflammation in the pathogenesis of neurological diseases has gained increasing attention, with a particular focus on its effects...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/578480 |
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| _version_ | 1850222059836145664 |
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| author | Kate Marie Lewis Renée Jade Turner Robert Vink |
| author_facet | Kate Marie Lewis Renée Jade Turner Robert Vink |
| author_sort | Kate Marie Lewis |
| collection | DOAJ |
| description | Classical inflammation is a well-characterized secondary response to many acute disorders of the central nervous system. However, in recent years, the role of neurogenic inflammation in the pathogenesis of neurological diseases has gained increasing attention, with a particular focus on its effects on modulation of the blood-brain barrier BBB. The neuropeptide substance P has been shown to increase blood-brain barrier permeability following acute injury to the brain and is associated with marked cerebral edema. Its release has also been shown to modulate classical inflammation. Accordingly, blocking substance P NK1 receptors may provide a novel alternative treatment to ameliorate the deleterious effects of neurogenic inflammation in the central nervous system. The purpose of this paper is to provide an overview of the role of substance P and neurogenic inflammation in acute injury to the central nervous system following traumatic brain injury, spinal cord injury, stroke, and meningitis. |
| format | Article |
| id | doaj-art-6e60c2b4b5924daaa2e4b9ee7aaa323f |
| institution | OA Journals |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-6e60c2b4b5924daaa2e4b9ee7aaa323f2025-08-20T02:06:28ZengWileyInternational Journal of Inflammation2090-80402042-00992013-01-01201310.1155/2013/578480578480Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous SystemKate Marie Lewis0Renée Jade Turner1Robert Vink2Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, North Terrace, SA 5005, AustraliaAdelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, North Terrace, SA 5005, AustraliaAdelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, North Terrace, SA 5005, AustraliaClassical inflammation is a well-characterized secondary response to many acute disorders of the central nervous system. However, in recent years, the role of neurogenic inflammation in the pathogenesis of neurological diseases has gained increasing attention, with a particular focus on its effects on modulation of the blood-brain barrier BBB. The neuropeptide substance P has been shown to increase blood-brain barrier permeability following acute injury to the brain and is associated with marked cerebral edema. Its release has also been shown to modulate classical inflammation. Accordingly, blocking substance P NK1 receptors may provide a novel alternative treatment to ameliorate the deleterious effects of neurogenic inflammation in the central nervous system. The purpose of this paper is to provide an overview of the role of substance P and neurogenic inflammation in acute injury to the central nervous system following traumatic brain injury, spinal cord injury, stroke, and meningitis.http://dx.doi.org/10.1155/2013/578480 |
| spellingShingle | Kate Marie Lewis Renée Jade Turner Robert Vink Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System International Journal of Inflammation |
| title | Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System |
| title_full | Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System |
| title_fullStr | Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System |
| title_full_unstemmed | Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System |
| title_short | Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System |
| title_sort | blocking neurogenic inflammation for the treatment of acute disorders of the central nervous system |
| url | http://dx.doi.org/10.1155/2013/578480 |
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