ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS
Studies have shown that exposure to organophosphates (OPs) is associated with increased frequency of gastrointestinal diseases. In order to evaluate the effect of dysfunction of detoxification system on the development of gastrointestinal pathology, we studied «esterase status» (activity of acetylch...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2017-03-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/375 |
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| author | A. V. Fomichev V. V. Miroshnikova U. S. Chalimov V. U. Golofeevskiy A. V. Yazenok V. G. Kuzmich K. V. Muzurov E. V. Malysheva S. N. Pchelina |
| author_facet | A. V. Fomichev V. V. Miroshnikova U. S. Chalimov V. U. Golofeevskiy A. V. Yazenok V. G. Kuzmich K. V. Muzurov E. V. Malysheva S. N. Pchelina |
| author_sort | A. V. Fomichev |
| collection | DOAJ |
| description | Studies have shown that exposure to organophosphates (OPs) is associated with increased frequency of gastrointestinal diseases. In order to evaluate the effect of dysfunction of detoxification system on the development of gastrointestinal pathology, we studied «esterase status» (activity of acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 (PON1)) among workers at the plants providing storage and disposal of OPs. The enzymatic activity of PON1 was significantly increased in individuals who had prolonged direct contact with the OPs. It was shown that among all gastrointestinal diseases included in this study PON1 activity was increased in patients with chronic esophagitis and chronic gastritis as compared to workers without gastrointestinal diseases (p<0.05), so and with diseased workers who had no direct contact with OPs (p<0.05). Thus, changes in PON1 activity may contribute to development of the gastrointestinal pathology among persons having direct contact with OPs. |
| format | Article |
| id | doaj-art-6e5e57e3e28e4733947e5c24fdc77a5d |
| institution | Kabale University |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-6e5e57e3e28e4733947e5c24fdc77a5d2025-08-20T03:35:28ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072017-03-01241525710.24884/1607-4181-2017-24-1-52-57335ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDSA. V. Fomichev0V. V. Miroshnikova1U. S. Chalimov2V. U. Golofeevskiy3A. V. Yazenok4V. G. Kuzmich5K. V. Muzurov6E. V. Malysheva7S. N. Pchelina8S. M. Kirov Military Medical AcademyB. P. Konstantinov Petersburg Nuclear Physics Institute, National Research Centre «Kurchatov Institute»S. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyS. M. Kirov Military Medical AcademyB. P. Konstantinov Petersburg Nuclear Physics Institute, National Research Centre «Kurchatov Institute»; Federal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion FederationStudies have shown that exposure to organophosphates (OPs) is associated with increased frequency of gastrointestinal diseases. In order to evaluate the effect of dysfunction of detoxification system on the development of gastrointestinal pathology, we studied «esterase status» (activity of acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 (PON1)) among workers at the plants providing storage and disposal of OPs. The enzymatic activity of PON1 was significantly increased in individuals who had prolonged direct contact with the OPs. It was shown that among all gastrointestinal diseases included in this study PON1 activity was increased in patients with chronic esophagitis and chronic gastritis as compared to workers without gastrointestinal diseases (p<0.05), so and with diseased workers who had no direct contact with OPs (p<0.05). Thus, changes in PON1 activity may contribute to development of the gastrointestinal pathology among persons having direct contact with OPs.https://www.sci-notes.ru/jour/article/view/375organophosphatesgastrointestinal pathologyparaoxonase-1esterase state |
| spellingShingle | A. V. Fomichev V. V. Miroshnikova U. S. Chalimov V. U. Golofeevskiy A. V. Yazenok V. G. Kuzmich K. V. Muzurov E. V. Malysheva S. N. Pchelina ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова organophosphates gastrointestinal pathology paraoxonase-1 esterase state |
| title | ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS |
| title_full | ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS |
| title_fullStr | ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS |
| title_full_unstemmed | ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS |
| title_short | ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS |
| title_sort | esterase activity among patients with gastrointestinal diseases working at the plants providing storage and disposal of organophosphorus compounds |
| topic | organophosphates gastrointestinal pathology paraoxonase-1 esterase state |
| url | https://www.sci-notes.ru/jour/article/view/375 |
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