Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water
Abstract SiO2 nanoparticles (SNPs), which are abundant in water and are used for various applications, for example, as food additives and anticaking agents, are of growing concern because of rising exposure to human health. Research has reported low potential side effects in animal models treated wi...
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BMC
2024-12-01
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| Series: | Sustainable Environment Research |
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| Online Access: | https://doi.org/10.1186/s42834-024-00237-7 |
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| author | Tzung Cheng Ye Shu-Ju Chao Chihpin Huang Ru-Tsun Mai |
| author_facet | Tzung Cheng Ye Shu-Ju Chao Chihpin Huang Ru-Tsun Mai |
| author_sort | Tzung Cheng Ye |
| collection | DOAJ |
| description | Abstract SiO2 nanoparticles (SNPs), which are abundant in water and are used for various applications, for example, as food additives and anticaking agents, are of growing concern because of rising exposure to human health. Research has reported low potential side effects in animal models treated with SNPs; however, a few in vivo studies have shown cause for concern. Presently, high-fat foods have changed our lives and increased the incidence rates of fatty liver, obesity, and overweight, and high-fat foods issue is prevalent in our modern society. To understand the rising SNPs exposure in life and modern dietary habits combined effect, we design experiments to study this research. Institute of Cancer Research mice fed a normal or high-fat diet were treated with different concentrations of SNPs for long-term effects. Blood and liver tissue were collected and prepared for blood biochemical assays, histology analysis, silicon and triglycerides (TGs) accumulation, immunohistochemistry, fibrosis staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining to analyze the influence of the combination of SNPs and a high-fat diet. This research found that the presence of SNPs in drinking water with the consumption of a high-fat diet was associated with the accumulation of SNPs and TGs in liver tissue, elevated aspartate aminotransferase and alanine aminotransferase levels in serum, activation of fibrosis and inflammation, increased oxidative stress through 4-hydroxynonenal, and the development of liver steatosis. The results showed that the long-term effect of SNPs in drinking water might induce liver steatosis, particularly under modern dietary habits such as a high-fat diet. This study investigated the interactions between environmental nanoparticles, such as the long-term risk of exposure to SNPs, and dietary factors, suggesting a significant risk to liver health, especially in human health. |
| format | Article |
| id | doaj-art-6e5cfdbc5554499b9eda87f00e9791e6 |
| institution | OA Journals |
| issn | 2468-2039 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Sustainable Environment Research |
| spelling | doaj-art-6e5cfdbc5554499b9eda87f00e9791e62025-08-20T01:57:13ZengBMCSustainable Environment Research2468-20392024-12-0134112010.1186/s42834-024-00237-7Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking waterTzung Cheng Ye0Shu-Ju Chao1Chihpin Huang2Ru-Tsun Mai3Institute of Environmental Engineering, National Yang Ming Chiao Tung UniversityInstitute of Environmental Engineering, National Yang Ming Chiao Tung UniversityInstitute of Environmental Engineering, National Yang Ming Chiao Tung UniversityDepartment of Biological Science & Technology, National Yang Ming Chiao Tung UniversityAbstract SiO2 nanoparticles (SNPs), which are abundant in water and are used for various applications, for example, as food additives and anticaking agents, are of growing concern because of rising exposure to human health. Research has reported low potential side effects in animal models treated with SNPs; however, a few in vivo studies have shown cause for concern. Presently, high-fat foods have changed our lives and increased the incidence rates of fatty liver, obesity, and overweight, and high-fat foods issue is prevalent in our modern society. To understand the rising SNPs exposure in life and modern dietary habits combined effect, we design experiments to study this research. Institute of Cancer Research mice fed a normal or high-fat diet were treated with different concentrations of SNPs for long-term effects. Blood and liver tissue were collected and prepared for blood biochemical assays, histology analysis, silicon and triglycerides (TGs) accumulation, immunohistochemistry, fibrosis staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining to analyze the influence of the combination of SNPs and a high-fat diet. This research found that the presence of SNPs in drinking water with the consumption of a high-fat diet was associated with the accumulation of SNPs and TGs in liver tissue, elevated aspartate aminotransferase and alanine aminotransferase levels in serum, activation of fibrosis and inflammation, increased oxidative stress through 4-hydroxynonenal, and the development of liver steatosis. The results showed that the long-term effect of SNPs in drinking water might induce liver steatosis, particularly under modern dietary habits such as a high-fat diet. This study investigated the interactions between environmental nanoparticles, such as the long-term risk of exposure to SNPs, and dietary factors, suggesting a significant risk to liver health, especially in human health.https://doi.org/10.1186/s42834-024-00237-7Drinking waterHigh-fat dietNormal dietNanoparticlesFatty liverSteatosis |
| spellingShingle | Tzung Cheng Ye Shu-Ju Chao Chihpin Huang Ru-Tsun Mai Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water Sustainable Environment Research Drinking water High-fat diet Normal diet Nanoparticles Fatty liver Steatosis |
| title | Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water |
| title_full | Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water |
| title_fullStr | Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water |
| title_full_unstemmed | Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water |
| title_short | Aggravated liver steatosis in a modern dietary mouse model via long-term treatment of SiO2 nanoparticles in drinking water |
| title_sort | aggravated liver steatosis in a modern dietary mouse model via long term treatment of sio2 nanoparticles in drinking water |
| topic | Drinking water High-fat diet Normal diet Nanoparticles Fatty liver Steatosis |
| url | https://doi.org/10.1186/s42834-024-00237-7 |
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