RNA editing is induced by type I interferon in esophageal squamous cell carcinoma
In recent years, abnormal RNA editing has been shown to play an important role in the development of esophageal squamous cell carcinoma, as such abnormal editing is catalyzed by ADAR (adenosine deaminases acting on RNA). However, the regulatory mechanism of ADAR1 in esophageal squamous cell carcinom...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-07-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317708546 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414160678387712 |
|---|---|
| author | Jinyao Zhang Zhaoli Chen Zefang Tang Jianbing Huang Xueda Hu Jie He |
| author_facet | Jinyao Zhang Zhaoli Chen Zefang Tang Jianbing Huang Xueda Hu Jie He |
| author_sort | Jinyao Zhang |
| collection | DOAJ |
| description | In recent years, abnormal RNA editing has been shown to play an important role in the development of esophageal squamous cell carcinoma, as such abnormal editing is catalyzed by ADAR (adenosine deaminases acting on RNA). However, the regulatory mechanism of ADAR1 in esophageal squamous cell carcinomas remains largely unknown. In this study, we investigated ADAR1 expression and its association with RNA editing in esophageal squamous cell carcinomas. RNA sequencing applied to esophageal squamous cell carcinoma clinical samples showed that ADAR1 expression was correlated with the expression of STAT1, STAT2 , and IRF9 . In vitro experiments showed that the abundance of ADAR1 protein was associated with the induced activation of the JAK/STAT pathway by type I interferon. RNA sequencing results showed that treatment with type I interferon caused an increase in the number and degree of RNA editing in esophageal squamous cell carcinoma cell lines. In conclusion, the activation of the JAK/STAT pathway is a regulatory mechanism of ADAR1 expression and causes abnormal RNA editing profile in esophageal squamous cell carcinoma. This mechanism may serve as a new target for esophageal squamous cell carcinoma therapy. |
| format | Article |
| id | doaj-art-6e5ccd72ed5f4489986ce06c8a2294ec |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-6e5ccd72ed5f4489986ce06c8a2294ec2025-08-20T03:33:54ZengSAGE PublishingTumor Biology1423-03802017-07-013910.1177/1010428317708546RNA editing is induced by type I interferon in esophageal squamous cell carcinomaJinyao Zhang0Zhaoli Chen1Zefang Tang2Jianbing Huang3Xueda Hu4Jie He5Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBiodynamic Optical Imaging Center (BIOPIC), College of Life Sciences, Peking University, Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBiodynamic Optical Imaging Center (BIOPIC), College of Life Sciences, Peking University, Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaIn recent years, abnormal RNA editing has been shown to play an important role in the development of esophageal squamous cell carcinoma, as such abnormal editing is catalyzed by ADAR (adenosine deaminases acting on RNA). However, the regulatory mechanism of ADAR1 in esophageal squamous cell carcinomas remains largely unknown. In this study, we investigated ADAR1 expression and its association with RNA editing in esophageal squamous cell carcinomas. RNA sequencing applied to esophageal squamous cell carcinoma clinical samples showed that ADAR1 expression was correlated with the expression of STAT1, STAT2 , and IRF9 . In vitro experiments showed that the abundance of ADAR1 protein was associated with the induced activation of the JAK/STAT pathway by type I interferon. RNA sequencing results showed that treatment with type I interferon caused an increase in the number and degree of RNA editing in esophageal squamous cell carcinoma cell lines. In conclusion, the activation of the JAK/STAT pathway is a regulatory mechanism of ADAR1 expression and causes abnormal RNA editing profile in esophageal squamous cell carcinoma. This mechanism may serve as a new target for esophageal squamous cell carcinoma therapy.https://doi.org/10.1177/1010428317708546 |
| spellingShingle | Jinyao Zhang Zhaoli Chen Zefang Tang Jianbing Huang Xueda Hu Jie He RNA editing is induced by type I interferon in esophageal squamous cell carcinoma Tumor Biology |
| title | RNA editing is induced by type I interferon in esophageal squamous cell carcinoma |
| title_full | RNA editing is induced by type I interferon in esophageal squamous cell carcinoma |
| title_fullStr | RNA editing is induced by type I interferon in esophageal squamous cell carcinoma |
| title_full_unstemmed | RNA editing is induced by type I interferon in esophageal squamous cell carcinoma |
| title_short | RNA editing is induced by type I interferon in esophageal squamous cell carcinoma |
| title_sort | rna editing is induced by type i interferon in esophageal squamous cell carcinoma |
| url | https://doi.org/10.1177/1010428317708546 |
| work_keys_str_mv | AT jinyaozhang rnaeditingisinducedbytypeiinterferoninesophagealsquamouscellcarcinoma AT zhaolichen rnaeditingisinducedbytypeiinterferoninesophagealsquamouscellcarcinoma AT zefangtang rnaeditingisinducedbytypeiinterferoninesophagealsquamouscellcarcinoma AT jianbinghuang rnaeditingisinducedbytypeiinterferoninesophagealsquamouscellcarcinoma AT xuedahu rnaeditingisinducedbytypeiinterferoninesophagealsquamouscellcarcinoma AT jiehe rnaeditingisinducedbytypeiinterferoninesophagealsquamouscellcarcinoma |