3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression

3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression

Abstract Colorectal carcinoma (CRC) is a deadly cancer with an aggressive nature, and how CRC tumor cells manage to translocate and proliferate in a new tissue environment remains not fully understood. Recently, higher-order chromatin structures and spatial genome organization are increasingly impli...

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Main Authors: Xiang Xu, Jingbo Gan, Zhaoya Gao, Ruifeng Li, Dandan Huang, Lin Lin, Yawen Luo, Qian Yang, Jingxuan Xu, Yaru Li, Qing Fang, Ting Peng, Yaqi Wang, Zihan Xu, An Huang, Haopeng Hong, Fuming Lei, Wensheng Huang, Jianjun Leng, Tingting Li, Xiaochen Bo, Hebing Chen, Cheng Li, Jin Gu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07647-2
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