Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus
Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Althou...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/7586719 |
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| author | Ryan Leibrandt Kenneth Angelino Monique Vizel-Schwartz Ilan Shapira |
| author_facet | Ryan Leibrandt Kenneth Angelino Monique Vizel-Schwartz Ilan Shapira |
| author_sort | Ryan Leibrandt |
| collection | DOAJ |
| description | Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. The Donath–Landsteiner (DL) test, the diagnostic test for PCH, was positive on two separate occasions. The patient was treated successfully with warming and avoidance of cold temperatures. To facilitate identification of this rare entity by clinicians, we include a discussion about the pathophysiology, diagnosis, and treatment of PCH. |
| format | Article |
| id | doaj-art-6e584efbf9074714b8e1198dbc3a3fe3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6e584efbf9074714b8e1198dbc3a3fe32025-02-03T05:52:14ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/75867197586719Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial VirusRyan Leibrandt0Kenneth Angelino1Monique Vizel-Schwartz2Ilan Shapira3Department of Medicine, Mount Sinai Beth Israel, New York, NY, USADivision of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Hospital, New York, NY, USADivision of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USADivision of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USAParoxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. The Donath–Landsteiner (DL) test, the diagnostic test for PCH, was positive on two separate occasions. The patient was treated successfully with warming and avoidance of cold temperatures. To facilitate identification of this rare entity by clinicians, we include a discussion about the pathophysiology, diagnosis, and treatment of PCH.http://dx.doi.org/10.1155/2018/7586719 |
| spellingShingle | Ryan Leibrandt Kenneth Angelino Monique Vizel-Schwartz Ilan Shapira Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus Case Reports in Hematology |
| title | Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus |
| title_full | Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus |
| title_fullStr | Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus |
| title_full_unstemmed | Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus |
| title_short | Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus |
| title_sort | paroxysmal cold hemoglobinuria in an adult with respiratory syncytial virus |
| url | http://dx.doi.org/10.1155/2018/7586719 |
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