519 Staphylococcus colonization drives IFN-mediated monocyte recruitment and skin barrier disruption in cutaneous lupus erythematosus lesions

519 Staphylococcus colonization drives IFN-mediated monocyte recruitment and skin barrier disruption in cutaneous lupus erythematosus lesions

Objectives/Goals: Cutaneous lupus erythematosus (CLE) is an inflammatory skin manifestation of lupus. CLE lesions are frequently colonized by Staphylococcus aureus, a microbe known to promote IFN production and inflammation. Here, we investigate whether type I IFN and inflammatory gene signatures in...

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Main Authors: Lisa Abernathy-Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Annie Lu, Zeran Zhang, Amy Hurst, J Michelle Kahlenberg
Format: Article
Language:English
Published: Cambridge University Press 2025-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866124010999/type/journal_article
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