Multi-omics: a bridge connecting genotype and phenotype for epilepsy?
Abstract Epilepsy is a collection of neurological disorders characterized by abnormal neuronal discharges, resulting in spontaneous and recurrent unprovoked seizures. Despite the use of over 20 anti-seizure drugs, conventional one-size-fits-all approaches are insufficient to meet the needs of all pa...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-025-00798-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850111699527401472 |
|---|---|
| author | Nan-Nan Wang Fei Cao Lin-Han Zhang Yi-Fei Zheng Da Xu |
| author_facet | Nan-Nan Wang Fei Cao Lin-Han Zhang Yi-Fei Zheng Da Xu |
| author_sort | Nan-Nan Wang |
| collection | DOAJ |
| description | Abstract Epilepsy is a collection of neurological disorders characterized by abnormal neuronal discharges, resulting in spontaneous and recurrent unprovoked seizures. Despite the use of over 20 anti-seizure drugs, conventional one-size-fits-all approaches are insufficient to meet the needs of all patients, and about 1/3 patients developed drug-resistant epilepsy. Recently, the establishment of precision medicine-based clinical management for epilepsy may bring new insights, especially omics-based approaches. Single omics approach is limited to addressing questions from a single molecular perspective. Whereas multi-omics approaches enable a comprehensive characterization of multiple molecules, revealing the complex molecular dysregulation networks underlying different epilepsy phenotypes. Furthermore, multi-omics methods have catalyzed a paradigm shift in scientific inquiry, transitioning from traditional hypothesis-driven types to data-driven research architectures. Despite the full potential of multi-omics research yet to be realized, its application in epilepsy holds great promise, from the discovery of epileptic biomarkers to personalized management. In this review, we performed a comprehensive overview of the omics technologies and multi-omics integration strategies, followed by an exploration of their role in enhancing the management of epilepsy treatment and care, hoping to provide new directions for future researches. |
| format | Article |
| id | doaj-art-6e4ae985b8e54ef5bc87b21451356e42 |
| institution | OA Journals |
| issn | 2050-7771 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-6e4ae985b8e54ef5bc87b21451356e422025-08-20T02:37:34ZengBMCBiomarker Research2050-77712025-06-0113111810.1186/s40364-025-00798-8Multi-omics: a bridge connecting genotype and phenotype for epilepsy?Nan-Nan Wang0Fei Cao1Lin-Han Zhang2Yi-Fei Zheng3Da Xu4Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Epilepsy is a collection of neurological disorders characterized by abnormal neuronal discharges, resulting in spontaneous and recurrent unprovoked seizures. Despite the use of over 20 anti-seizure drugs, conventional one-size-fits-all approaches are insufficient to meet the needs of all patients, and about 1/3 patients developed drug-resistant epilepsy. Recently, the establishment of precision medicine-based clinical management for epilepsy may bring new insights, especially omics-based approaches. Single omics approach is limited to addressing questions from a single molecular perspective. Whereas multi-omics approaches enable a comprehensive characterization of multiple molecules, revealing the complex molecular dysregulation networks underlying different epilepsy phenotypes. Furthermore, multi-omics methods have catalyzed a paradigm shift in scientific inquiry, transitioning from traditional hypothesis-driven types to data-driven research architectures. Despite the full potential of multi-omics research yet to be realized, its application in epilepsy holds great promise, from the discovery of epileptic biomarkers to personalized management. In this review, we performed a comprehensive overview of the omics technologies and multi-omics integration strategies, followed by an exploration of their role in enhancing the management of epilepsy treatment and care, hoping to provide new directions for future researches.https://doi.org/10.1186/s40364-025-00798-8EpilepsyMulti-omics approachesSingle-cell omicsSpatial omicsBiomarkersDrug target |
| spellingShingle | Nan-Nan Wang Fei Cao Lin-Han Zhang Yi-Fei Zheng Da Xu Multi-omics: a bridge connecting genotype and phenotype for epilepsy? Biomarker Research Epilepsy Multi-omics approaches Single-cell omics Spatial omics Biomarkers Drug target |
| title | Multi-omics: a bridge connecting genotype and phenotype for epilepsy? |
| title_full | Multi-omics: a bridge connecting genotype and phenotype for epilepsy? |
| title_fullStr | Multi-omics: a bridge connecting genotype and phenotype for epilepsy? |
| title_full_unstemmed | Multi-omics: a bridge connecting genotype and phenotype for epilepsy? |
| title_short | Multi-omics: a bridge connecting genotype and phenotype for epilepsy? |
| title_sort | multi omics a bridge connecting genotype and phenotype for epilepsy |
| topic | Epilepsy Multi-omics approaches Single-cell omics Spatial omics Biomarkers Drug target |
| url | https://doi.org/10.1186/s40364-025-00798-8 |
| work_keys_str_mv | AT nannanwang multiomicsabridgeconnectinggenotypeandphenotypeforepilepsy AT feicao multiomicsabridgeconnectinggenotypeandphenotypeforepilepsy AT linhanzhang multiomicsabridgeconnectinggenotypeandphenotypeforepilepsy AT yifeizheng multiomicsabridgeconnectinggenotypeandphenotypeforepilepsy AT daxu multiomicsabridgeconnectinggenotypeandphenotypeforepilepsy |