Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study
Objectives. Clinically relevant postoperative pancreatic fistula (CR-POPF) is the considerable contributor to major complications after pancreatectomy. The purpose of this study was to evaluate the potential risk factor contributing to CR-POPF following distal pancreatectomy (DP) and discuss the ris...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/8874504 |
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| author | Gao Qing Wang Dipesh Kumar Yadav Wei Jiang Yong Fei Hua Cai De Lu |
| author_facet | Gao Qing Wang Dipesh Kumar Yadav Wei Jiang Yong Fei Hua Cai De Lu |
| author_sort | Gao Qing Wang |
| collection | DOAJ |
| description | Objectives. Clinically relevant postoperative pancreatic fistula (CR-POPF) is the considerable contributor to major complications after pancreatectomy. The purpose of this study was to evaluate the potential risk factor contributing to CR-POPF following distal pancreatectomy (DP) and discuss the risk factors of pancreatic fistula in order to interpret the clinical importance. Methods. In this retrospective study, 263 patients who underwent DP at Ningbo Medical Center Li Huili Hospital between January 2011 and January 2020 were reviewed in accordance with relevant guidelines and regulations. Patients’ demographics and clinical parameters were evaluated using univariate and multivariate analyses to identify the risk factors contributing to CR-POPF. P<0.05 was considered statistically significant. Results. In all of the 263 patients with DP, pancreatic fistula was the most common surgical complication (19.0%). The univariate analysis of 18 factors showed that the patients with a malignant tumor, soft pancreas, and patient without ligation of the main pancreatic duct were more likely to develop pancreatic fistula. However, on multivariate analysis, the soft texture of the pancreas (OR = 2.381, 95% CI = 1.271–4.460, P=0.001) and the ligation of the main pancreatic duct (OR = 0.388, 95% CI = 0.207–0.726, P=0.002) were only an independent influencing factor for CR-POPF. Conclusions. As a conclusion, pancreatic fistula was the most common surgical complication after DP. The soft texture of the pancreas and the absence of ligation of the main pancreatic duct can increase the risk of CR-POPF. |
| format | Article |
| id | doaj-art-6e4ac76dcb3343b48011791dcbb7eceb |
| institution | OA Journals |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-6e4ac76dcb3343b48011791dcbb7eceb2025-08-20T02:06:30ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/88745048874504Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective StudyGao Qing Wang0Dipesh Kumar Yadav1Wei Jiang2Yong Fei Hua3Cai De Lu4Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center LiHuiLi Hospital, Ningbo 315040, Zhejiang, ChinaDepartment of Hepatobiliary Surgery & Liver Transplantation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center LiHuiLi Hospital, Ningbo 315040, Zhejiang, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center LiHuiLi Hospital, Ningbo 315040, Zhejiang, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center LiHuiLi Hospital, Ningbo 315040, Zhejiang, ChinaObjectives. Clinically relevant postoperative pancreatic fistula (CR-POPF) is the considerable contributor to major complications after pancreatectomy. The purpose of this study was to evaluate the potential risk factor contributing to CR-POPF following distal pancreatectomy (DP) and discuss the risk factors of pancreatic fistula in order to interpret the clinical importance. Methods. In this retrospective study, 263 patients who underwent DP at Ningbo Medical Center Li Huili Hospital between January 2011 and January 2020 were reviewed in accordance with relevant guidelines and regulations. Patients’ demographics and clinical parameters were evaluated using univariate and multivariate analyses to identify the risk factors contributing to CR-POPF. P<0.05 was considered statistically significant. Results. In all of the 263 patients with DP, pancreatic fistula was the most common surgical complication (19.0%). The univariate analysis of 18 factors showed that the patients with a malignant tumor, soft pancreas, and patient without ligation of the main pancreatic duct were more likely to develop pancreatic fistula. However, on multivariate analysis, the soft texture of the pancreas (OR = 2.381, 95% CI = 1.271–4.460, P=0.001) and the ligation of the main pancreatic duct (OR = 0.388, 95% CI = 0.207–0.726, P=0.002) were only an independent influencing factor for CR-POPF. Conclusions. As a conclusion, pancreatic fistula was the most common surgical complication after DP. The soft texture of the pancreas and the absence of ligation of the main pancreatic duct can increase the risk of CR-POPF.http://dx.doi.org/10.1155/2021/8874504 |
| spellingShingle | Gao Qing Wang Dipesh Kumar Yadav Wei Jiang Yong Fei Hua Cai De Lu Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study Canadian Journal of Gastroenterology and Hepatology |
| title | Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study |
| title_full | Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study |
| title_fullStr | Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study |
| title_full_unstemmed | Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study |
| title_short | Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula (CR-POPF) after Distal Pancreatectomy: A Single Center Retrospective Study |
| title_sort | risk factors for clinically relevant postoperative pancreatic fistula cr popf after distal pancreatectomy a single center retrospective study |
| url | http://dx.doi.org/10.1155/2021/8874504 |
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