The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study
Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2331614 |
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| author | Lingling Xu Dongling Li Zongwei Song Jin Liu Yang Zhou Junwei Yang Ping Wen |
| author_facet | Lingling Xu Dongling Li Zongwei Song Jin Liu Yang Zhou Junwei Yang Ping Wen |
| author_sort | Lingling Xu |
| collection | DOAJ |
| description | Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population.Methods In this cross-sectional study, 232,775 community-dwelling adults in Binhai who completed health checkups in 2021 were enrolled. Participants were categorized based on the MHR quartiles. Clinical characteristics of participants across different groups were compared using one-way ANOVA, Kruskal-Wallis h-test, and Chi-squared test as appropriate. Univariate and multivariable logistic regression analyses were taken to assess the relationship between MHR and the presence of CKD, as well as its association with low estimated glomerular filtration rate (eGFR) and proteinuria. Subgroup analyses were further executed to confirm the reliability of this relationship.Results A total of 21,014 (9.0%) individuals were diagnosed with CKD. Characteristic indicators including waist circumference, body mass index (BMI), blood pressure (BP), serum uric acid (SUA), triglyceride, and fasting blood glucose (FBG) showed a gradual increase with higher MHR quartiles, whereas parameters such as age, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and eGFR decreased (p < .001). In the multivariable logistic regression analysis, we observed independent associations between MHR (per 1 SD increase) and CKD, as well as low eGFR and proteinuria, with odds ratio (ORs) and 95% confidence intervals (95%CIs) of 1.206 (1.186–1.225), 1.289 (1.260–1.319), and 1.150 (1.129–1.171), respectively (p < .001). Similar conclusions were confirmed in subgroup analysis stratified by gender, age, BMI, central obesity, hypertension, and diabetes mellitus, after justification for confounding factors.Conclusion Elevated MHR level was independently associated with the presence of CKD, suggesting that it might serve as a useful clinical tool for risk stratification, offering valuable insights to inform preventive and therapeutic approaches for clinicians in their routine medical practice. |
| format | Article |
| id | doaj-art-6e49b84759614bd2b320a413c4dd9ac8 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-6e49b84759614bd2b320a413c4dd9ac82025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2331614The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional studyLingling Xu0Dongling Li1Zongwei Song2Jin Liu3Yang Zhou4Junwei Yang5Ping Wen6Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Nephrology, People’s Hospital of Binhai County, Yancheng, Jiangsu, ChinaCenter for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCenter for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCenter for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCenter for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCenter for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaBackground Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population.Methods In this cross-sectional study, 232,775 community-dwelling adults in Binhai who completed health checkups in 2021 were enrolled. Participants were categorized based on the MHR quartiles. Clinical characteristics of participants across different groups were compared using one-way ANOVA, Kruskal-Wallis h-test, and Chi-squared test as appropriate. Univariate and multivariable logistic regression analyses were taken to assess the relationship between MHR and the presence of CKD, as well as its association with low estimated glomerular filtration rate (eGFR) and proteinuria. Subgroup analyses were further executed to confirm the reliability of this relationship.Results A total of 21,014 (9.0%) individuals were diagnosed with CKD. Characteristic indicators including waist circumference, body mass index (BMI), blood pressure (BP), serum uric acid (SUA), triglyceride, and fasting blood glucose (FBG) showed a gradual increase with higher MHR quartiles, whereas parameters such as age, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and eGFR decreased (p < .001). In the multivariable logistic regression analysis, we observed independent associations between MHR (per 1 SD increase) and CKD, as well as low eGFR and proteinuria, with odds ratio (ORs) and 95% confidence intervals (95%CIs) of 1.206 (1.186–1.225), 1.289 (1.260–1.319), and 1.150 (1.129–1.171), respectively (p < .001). Similar conclusions were confirmed in subgroup analysis stratified by gender, age, BMI, central obesity, hypertension, and diabetes mellitus, after justification for confounding factors.Conclusion Elevated MHR level was independently associated with the presence of CKD, suggesting that it might serve as a useful clinical tool for risk stratification, offering valuable insights to inform preventive and therapeutic approaches for clinicians in their routine medical practice.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2331614Chronic kidney diseaseinflammationmonocyte to high-density lipoprotein cholesterol ratiodyslipidemia |
| spellingShingle | Lingling Xu Dongling Li Zongwei Song Jin Liu Yang Zhou Junwei Yang Ping Wen The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study Renal Failure Chronic kidney disease inflammation monocyte to high-density lipoprotein cholesterol ratio dyslipidemia |
| title | The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study |
| title_full | The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study |
| title_fullStr | The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study |
| title_full_unstemmed | The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study |
| title_short | The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study |
| title_sort | association between monocyte to high density lipoprotein cholesterol ratio and chronic kidney disease in a chinese adult population a cross sectional study |
| topic | Chronic kidney disease inflammation monocyte to high-density lipoprotein cholesterol ratio dyslipidemia |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2331614 |
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