The impact of cellular environment on in vitro drug screening
There are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-10-01
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| Series: | Future Science OA |
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| Online Access: | https://www.future-science.com/doi/10.2144/fsoa-2023-0027 |
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| _version_ | 1850152217158352896 |
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| author | Aiman Moldasheva Laura Bakyt Denis Bulanin Mohamad Aljofan |
| author_facet | Aiman Moldasheva Laura Bakyt Denis Bulanin Mohamad Aljofan |
| author_sort | Aiman Moldasheva |
| collection | DOAJ |
| description | There are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of human phenotypical cells relevant to the condition may provide more accurate screening results, they are susceptible to producing false positives as cells are continuously influenced by constant chemical and physical interaction with the surrounding microenvironment. Therefore, several microenvironmental and pharmacomechanical aspects must be factored in during tissue culture drug screening. |
| format | Article |
| id | doaj-art-6e47632f5cb345019a0bf9082c3a8a35 |
| institution | OA Journals |
| issn | 2056-5623 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-6e47632f5cb345019a0bf9082c3a8a352025-08-20T02:26:02ZengTaylor & Francis GroupFuture Science OA2056-56232023-10-019910.2144/fsoa-2023-0027The impact of cellular environment on in vitro drug screeningAiman Moldasheva0Laura Bakyt1Denis Bulanin2Mohamad Aljofan31Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan1Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan1Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan1Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, KazakhstanThere are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of human phenotypical cells relevant to the condition may provide more accurate screening results, they are susceptible to producing false positives as cells are continuously influenced by constant chemical and physical interaction with the surrounding microenvironment. Therefore, several microenvironmental and pharmacomechanical aspects must be factored in during tissue culture drug screening.https://www.future-science.com/doi/10.2144/fsoa-2023-0027cell culturedrug screeningmicroenvironmentoxidative tensionpHROS |
| spellingShingle | Aiman Moldasheva Laura Bakyt Denis Bulanin Mohamad Aljofan The impact of cellular environment on in vitro drug screening Future Science OA cell culture drug screening microenvironment oxidative tension pH ROS |
| title | The impact of cellular environment on in vitro drug screening |
| title_full | The impact of cellular environment on in vitro drug screening |
| title_fullStr | The impact of cellular environment on in vitro drug screening |
| title_full_unstemmed | The impact of cellular environment on in vitro drug screening |
| title_short | The impact of cellular environment on in vitro drug screening |
| title_sort | impact of cellular environment on in vitro drug screening |
| topic | cell culture drug screening microenvironment oxidative tension pH ROS |
| url | https://www.future-science.com/doi/10.2144/fsoa-2023-0027 |
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