Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases
Bone metabolism in bone tissue is constantly maintained in a state of dynamic equilibrium. The mass of bone and joint tissues is determined by both bone formation and bone resorption. It is hypothesized that disrupted metabolic balance leads to osteoporosis, osteoarthritis, rheumatoid arthritis, and...
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| Language: | English |
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China Science Publishing & Media Ltd.
2025-02-01
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| Series: | Acta Biochimica et Biophysica Sinica |
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| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2025020 |
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| author | Wu Zuping Guan Yuzhe Chen Qian Song Ruifeng Xie Jing Zhang Xin Wang Yan Chen Qianming Chen Xiaoyan |
| author_facet | Wu Zuping Guan Yuzhe Chen Qian Song Ruifeng Xie Jing Zhang Xin Wang Yan Chen Qianming Chen Xiaoyan |
| author_sort | Wu Zuping |
| collection | DOAJ |
| description | Bone metabolism in bone tissue is constantly maintained in a state of dynamic equilibrium. The mass of bone and joint tissues is determined by both bone formation and bone resorption. It is hypothesized that disrupted metabolic balance leads to osteoporosis, osteoarthritis, rheumatoid arthritis, and bone tumors. Such disruptions often manifest as either a reduction or abnormality in bone mass and are frequently accompanied by pathological changes such as inflammation, fractures, and pain. α-Ketoglutarate (α-KG) serves as a pivotal intermediate in various metabolic pathways in mammals, significantly contributing to cellular energy metabolism, amino acid metabolism, and other physiological processes. α-KG may be a therapeutic target for a variety of bone-related diseases, such as osteoporosis, osteoarthritis, and rheumatoid arthritis, because of its role in maintaining the metabolic balance of bone. After the application of α-KG, bone loss and inflammation in bone tissue are alleviated. This review focuses on the regulatory effects of α-KG on various cells in bone and joint tissues. Owing to the regulatory effect of α-KG on the balance of bone metabolism, the application of α-KG in the treatment of osteoporosis, osteoarthritis, rheumatoid arthritis, bone tumors, and other bone tissue diseases has been clarified. |
| format | Article |
| id | doaj-art-6e431a5225c2452dae0ec7f2f801e1ec |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-6e431a5225c2452dae0ec7f2f801e1ec2025-08-20T04:03:12ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452025-02-01571207122110.3724/abbs.202502020d259ccEssential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseasesWu Zuping0Guan Yuzhe1Chen Qian2Song Ruifeng3Xie Jing4Zhang Xin5Wang Yan6Chen Qianming7Chen Xiaoyan8["Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China"]["Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China"]["Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China"]["Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China"]["State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610064, China"]["Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250000, China"]["ShengSi County People’s Hospital, Zhoushan 316000, China"]["Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China"]["Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China"]Bone metabolism in bone tissue is constantly maintained in a state of dynamic equilibrium. The mass of bone and joint tissues is determined by both bone formation and bone resorption. It is hypothesized that disrupted metabolic balance leads to osteoporosis, osteoarthritis, rheumatoid arthritis, and bone tumors. Such disruptions often manifest as either a reduction or abnormality in bone mass and are frequently accompanied by pathological changes such as inflammation, fractures, and pain. α-Ketoglutarate (α-KG) serves as a pivotal intermediate in various metabolic pathways in mammals, significantly contributing to cellular energy metabolism, amino acid metabolism, and other physiological processes. α-KG may be a therapeutic target for a variety of bone-related diseases, such as osteoporosis, osteoarthritis, and rheumatoid arthritis, because of its role in maintaining the metabolic balance of bone. After the application of α-KG, bone loss and inflammation in bone tissue are alleviated. This review focuses on the regulatory effects of α-KG on various cells in bone and joint tissues. Owing to the regulatory effect of α-KG on the balance of bone metabolism, the application of α-KG in the treatment of osteoporosis, osteoarthritis, rheumatoid arthritis, bone tumors, and other bone tissue diseases has been clarified.https://www.sciengine.com/doi/10.3724/abbs.2025020α-ketoglutaratebone metabolismosteoporosisosteoarthritisrheumatoid arthritisperiodontitis |
| spellingShingle | Wu Zuping Guan Yuzhe Chen Qian Song Ruifeng Xie Jing Zhang Xin Wang Yan Chen Qianming Chen Xiaoyan Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases Acta Biochimica et Biophysica Sinica α-ketoglutarate bone metabolism osteoporosis osteoarthritis rheumatoid arthritis periodontitis |
| title | Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases |
| title_full | Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases |
| title_fullStr | Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases |
| title_full_unstemmed | Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases |
| title_short | Essential role of the metabolite α-ketoglutarate in bone tissue and bone-related diseases |
| title_sort | essential role of the metabolite α ketoglutarate in bone tissue and bone related diseases |
| topic | α-ketoglutarate bone metabolism osteoporosis osteoarthritis rheumatoid arthritis periodontitis |
| url | https://www.sciengine.com/doi/10.3724/abbs.2025020 |
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