Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids
A series of Mefenamic acid derivatives were designed and synthesized and the products were characterized spectroscopically using FT-IR, 1H NMR, and 13C NMR techniques. Series A included the transformation of six drugs (Mefenamic acid, Ampiciline, Noproxen, Benzilic acid, Diclofenac acid, and ceph...
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University of Baghdad, College of Science for Women
2024-12-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8657 |
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| author | Selvana A. Yousif |
| author_facet | Selvana A. Yousif |
| author_sort | Selvana A. Yousif |
| collection | DOAJ |
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A series of Mefenamic acid derivatives were designed and synthesized and the products were characterized spectroscopically using FT-IR, 1H NMR, and 13C NMR techniques. Series A included the transformation of six drugs (Mefenamic acid, Ampiciline, Noproxen, Benzilic acid, Diclofenac acid, and cephics) which are known to have highly medicinal effectiveness to acid chloride then react with thiosemicarbazide to synthesize series B. In the third stage, oxadiazole was prepared using POCl3 as a ring-closing agent to compounds (B1-B6). The final step in the strategy was building new Mefenamic acid derivatives consisting of condensation of the Mefenamic acid chloride with the compounds (C1-C6) to give new compounds (D1-D6).
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| format | Article |
| id | doaj-art-6e363c8500ec4a80a52cf2bd9d220e52 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-6e363c8500ec4a80a52cf2bd9d220e522025-08-20T03:33:54ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-12-012112(Suppl.)10.21123/bsj.2024.8657Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic AcidsSelvana A. Yousif 0Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq A series of Mefenamic acid derivatives were designed and synthesized and the products were characterized spectroscopically using FT-IR, 1H NMR, and 13C NMR techniques. Series A included the transformation of six drugs (Mefenamic acid, Ampiciline, Noproxen, Benzilic acid, Diclofenac acid, and cephics) which are known to have highly medicinal effectiveness to acid chloride then react with thiosemicarbazide to synthesize series B. In the third stage, oxadiazole was prepared using POCl3 as a ring-closing agent to compounds (B1-B6). The final step in the strategy was building new Mefenamic acid derivatives consisting of condensation of the Mefenamic acid chloride with the compounds (C1-C6) to give new compounds (D1-D6). https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8657Derivatives, Drugs, Mefenamic acid, Ring-closing, Synthesis oxadiazole. |
| spellingShingle | Selvana A. Yousif Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids مجلة بغداد للعلوم Derivatives, Drugs, Mefenamic acid, Ring-closing, Synthesis oxadiazole. |
| title | Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids |
| title_full | Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids |
| title_fullStr | Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids |
| title_full_unstemmed | Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids |
| title_short | Preparation, Characterization, of Some Oxadiazol Derivatives Prepared from Different Carboxylic Acids |
| title_sort | preparation characterization of some oxadiazol derivatives prepared from different carboxylic acids |
| topic | Derivatives, Drugs, Mefenamic acid, Ring-closing, Synthesis oxadiazole. |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8657 |
| work_keys_str_mv | AT selvanaayousif preparationcharacterizationofsomeoxadiazolderivativespreparedfromdifferentcarboxylicacids |