Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors
Background. Although it is possible to visualize gastrointestinal stromal tumors (GIST) of the stomach by endoscopy, their pretreatment histological diagnosis is often difficult. The aim of this study was to investigate predictors of accurate preoperative pathological diagnosis of gastric GIST. Mate...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/139083 |
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| author | Hiroaki Ito Haruhiro Inoue Shomei Ryozawa Haruo Ikeda Noriko Odaka Nikolas Eleftheriadis Roberta Maselli Norimasa Sando Satoshi Kimura Shin-ei Kudo |
| author_facet | Hiroaki Ito Haruhiro Inoue Shomei Ryozawa Haruo Ikeda Noriko Odaka Nikolas Eleftheriadis Roberta Maselli Norimasa Sando Satoshi Kimura Shin-ei Kudo |
| author_sort | Hiroaki Ito |
| collection | DOAJ |
| description | Background. Although it is possible to visualize gastrointestinal stromal tumors (GIST) of the stomach by endoscopy, their pretreatment histological diagnosis is often difficult. The aim of this study was to investigate predictors of accurate preoperative pathological diagnosis of gastric GIST. Material and Methods. We retrospectively studied patients with gastric GIST who had undergone pretreatment endoscopic biopsy and surgery, and examined their clinicopathological data. Results. Twenty-three patients were eligible. Thirty-four endoscopic biopsies (mean 2.6, range 1–8) were obtained. Preoperative pathological diagnoses of GIST were made in 18 patients. Precise diagnoses were made in 18 (52.9%) of the 34 biopsies. Endoscopic ultrasound (EUS) resulted in precise diagnoses in 11 (91.7%) of the 12 biopsy specimens. Fine-needle aspiration (FNA) biopsy resulted in precise diagnoses in 11 (84.6%) of the 13 biopsy specimens. The accuracy of pathological diagnosis by EUS-guided FNA biopsy was 100%. The procedure of EUS-guided FNA biopsy had no complications or recurrent disease. In a multivariate analysis, only EUS achieved a significantly superior rate of diagnosis (odds ratio, 11.884; 95% confidence interval, 1.204–289.230; P=0.034). Conclusion. EUS-guided FNA biopsy is the most accurate for pretreatment pathological diagnosis of gastric GIST and for prevention of both of early complications and disease recurrence. |
| format | Article |
| id | doaj-art-6e30c7fd80464a8f8c2d1f7d210bfa45 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-6e30c7fd80464a8f8c2d1f7d210bfa452025-02-03T01:25:54ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/139083139083Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal TumorsHiroaki Ito0Haruhiro Inoue1Shomei Ryozawa2Haruo Ikeda3Noriko Odaka4Nikolas Eleftheriadis5Roberta Maselli6Norimasa Sando7Satoshi Kimura8Shin-ei Kudo9Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanCentral Clinical Laboratory and Department of Laboratory Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanDigestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasakichuo, Tsuzuki-ku, Yokohama 224-8503, JapanBackground. Although it is possible to visualize gastrointestinal stromal tumors (GIST) of the stomach by endoscopy, their pretreatment histological diagnosis is often difficult. The aim of this study was to investigate predictors of accurate preoperative pathological diagnosis of gastric GIST. Material and Methods. We retrospectively studied patients with gastric GIST who had undergone pretreatment endoscopic biopsy and surgery, and examined their clinicopathological data. Results. Twenty-three patients were eligible. Thirty-four endoscopic biopsies (mean 2.6, range 1–8) were obtained. Preoperative pathological diagnoses of GIST were made in 18 patients. Precise diagnoses were made in 18 (52.9%) of the 34 biopsies. Endoscopic ultrasound (EUS) resulted in precise diagnoses in 11 (91.7%) of the 12 biopsy specimens. Fine-needle aspiration (FNA) biopsy resulted in precise diagnoses in 11 (84.6%) of the 13 biopsy specimens. The accuracy of pathological diagnosis by EUS-guided FNA biopsy was 100%. The procedure of EUS-guided FNA biopsy had no complications or recurrent disease. In a multivariate analysis, only EUS achieved a significantly superior rate of diagnosis (odds ratio, 11.884; 95% confidence interval, 1.204–289.230; P=0.034). Conclusion. EUS-guided FNA biopsy is the most accurate for pretreatment pathological diagnosis of gastric GIST and for prevention of both of early complications and disease recurrence.http://dx.doi.org/10.1155/2012/139083 |
| spellingShingle | Hiroaki Ito Haruhiro Inoue Shomei Ryozawa Haruo Ikeda Noriko Odaka Nikolas Eleftheriadis Roberta Maselli Norimasa Sando Satoshi Kimura Shin-ei Kudo Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors Gastroenterology Research and Practice |
| title | Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors |
| title_full | Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors |
| title_fullStr | Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors |
| title_full_unstemmed | Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors |
| title_short | Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors |
| title_sort | fine needle aspiration biopsy and endoscopic ultrasound for pretreatment pathological diagnosis of gastric gastrointestinal stromal tumors |
| url | http://dx.doi.org/10.1155/2012/139083 |
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