An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial...
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BioMed Central
2018-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2018-16-4-e21.pdf |
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| author | Soo Jin Jeon Klibs N. Galvão |
| author_facet | Soo Jin Jeon Klibs N. Galvão |
| author_sort | Soo Jin Jeon |
| collection | DOAJ |
| description | Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial and ovarian function are not fully recovered, which results in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Recent studies using high-throughput sequencing observed very low relative abundance of Escherichia coli, Trueperella pyogenes, and Prevotella melaninogenica in cows with metritis. Herein, we propose that metritis is associated with a dysbiosis of the uterine microbiota, which is characterized by high abundance of Bacteroides, Porphyromonas, and Fusobacterium. |
| format | Article |
| id | doaj-art-6e2deadd65c2475bb43fc912ebee1f8f |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-6e2deadd65c2475bb43fc912ebee1f8f2025-02-02T22:00:51ZengBioMed CentralGenomics & Informatics2234-07422018-12-0116410.5808/GI.2018.16.4.e21519An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy CowsSoo Jin Jeon0Klibs N. Galvão1 Department of Biomedical Veterinary Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USAMetritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial and ovarian function are not fully recovered, which results in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Recent studies using high-throughput sequencing observed very low relative abundance of Escherichia coli, Trueperella pyogenes, and Prevotella melaninogenica in cows with metritis. Herein, we propose that metritis is associated with a dysbiosis of the uterine microbiota, which is characterized by high abundance of Bacteroides, Porphyromonas, and Fusobacterium.http://genominfo.org/upload/pdf/gi-2018-16-4-e21.pdfcattlemetagenomicsmicrobiotauterine diseases |
| spellingShingle | Soo Jin Jeon Klibs N. Galvão An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows Genomics & Informatics cattle metagenomics microbiota uterine diseases |
| title | An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows |
| title_full | An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows |
| title_fullStr | An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows |
| title_full_unstemmed | An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows |
| title_short | An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows |
| title_sort | advanced understanding of uterine microbial ecology associated with metritis in dairy cows |
| topic | cattle metagenomics microbiota uterine diseases |
| url | http://genominfo.org/upload/pdf/gi-2018-16-4-e21.pdf |
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