An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows

Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial...

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Main Authors: Soo Jin Jeon, Klibs N. Galvão
Format: Article
Language:English
Published: BioMed Central 2018-12-01
Series:Genomics & Informatics
Subjects:
Online Access:http://genominfo.org/upload/pdf/gi-2018-16-4-e21.pdf
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author Soo Jin Jeon
Klibs N. Galvão
author_facet Soo Jin Jeon
Klibs N. Galvão
author_sort Soo Jin Jeon
collection DOAJ
description Metritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial and ovarian function are not fully recovered, which results in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Recent studies using high-throughput sequencing observed very low relative abundance of Escherichia coli, Trueperella pyogenes, and Prevotella melaninogenica in cows with metritis. Herein, we propose that metritis is associated with a dysbiosis of the uterine microbiota, which is characterized by high abundance of Bacteroides, Porphyromonas, and Fusobacterium.
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spelling doaj-art-6e2deadd65c2475bb43fc912ebee1f8f2025-02-02T22:00:51ZengBioMed CentralGenomics & Informatics2234-07422018-12-0116410.5808/GI.2018.16.4.e21519An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy CowsSoo Jin Jeon0Klibs N. Galvão1 Department of Biomedical Veterinary Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USAMetritis, the inflammation of the uterus caused by polymicrobial infections, is a prevalent and costly disease to the dairy industry as it decreases milk yield, survival, and the welfare of dairy cows. Although affected cows are treated with broad-spectrum antibiotics such as ceftiofur, endometrial and ovarian function are not fully recovered, which results in subfertility and infertility. According to culture-dependent studies, uterine pathogens include Escherichia coli, Trueperella pyogenes, Fusobacterium necrophorum, and Prevotella melaninogenica. Recent studies using high-throughput sequencing observed very low relative abundance of Escherichia coli, Trueperella pyogenes, and Prevotella melaninogenica in cows with metritis. Herein, we propose that metritis is associated with a dysbiosis of the uterine microbiota, which is characterized by high abundance of Bacteroides, Porphyromonas, and Fusobacterium.http://genominfo.org/upload/pdf/gi-2018-16-4-e21.pdfcattlemetagenomicsmicrobiotauterine diseases
spellingShingle Soo Jin Jeon
Klibs N. Galvão
An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
Genomics & Informatics
cattle
metagenomics
microbiota
uterine diseases
title An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
title_full An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
title_fullStr An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
title_full_unstemmed An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
title_short An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows
title_sort advanced understanding of uterine microbial ecology associated with metritis in dairy cows
topic cattle
metagenomics
microbiota
uterine diseases
url http://genominfo.org/upload/pdf/gi-2018-16-4-e21.pdf
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