Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes
Transition ion complexes have various commercial and technical uses, including antibacterial, antifungal, and anticancer medications and catalysts; their characteristics are critical regarding their kinetic impact. This study aims to synthesize new complexes, copper and nickel complexes, chara...
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University of Baghdad
2025-01-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
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| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3357 |
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| author | Elaf A. Mousa Basim I. Al-Abdaly |
| author_facet | Elaf A. Mousa Basim I. Al-Abdaly |
| author_sort | Elaf A. Mousa |
| collection | DOAJ |
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Transition ion complexes have various commercial and technical uses, including antibacterial, antifungal, and anticancer medications and catalysts; their characteristics are critical regarding their kinetic impact. This study aims to synthesize new complexes, copper and nickel complexes, characterize them using spectral techniques, determine their chloride content, evaluate their anti-oxidant effect, and examine the antibacterial activity of the ligands and their complexes against gram-positive bacteria (Staphylococcus), gram-negative bacteria (Escherichia coli), and Candida albicans. All chemicals were used strictly as provided, with no additional purification; CuCl2.2H2O and Ni(CH3CO2)2 salts were used to react with melatonin (L1), and one of the amino acids (L-cysteine) (L2) in a mole ratio of 1:1:1 (M: L1:L2) to produce mixed ligand metal complexes. The results showed that the two metal complexes were more active in (10–3 M) and had higher activity than the two ligands (melatonin and cysteine). According to the findings, the complexes have suggested structures: octahedral geometry for the Cu(II) complex and tetrahedral geometry for the Ni(II) complex. The scientific results demonstrated that the synthesized complexes have high antibacterial action against [Escherchiacoli (G-) (E. coli), Staphylococcus aureus (G+)], and antifungal action against [Candida (C. albicaus)].
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| format | Article |
| id | doaj-art-6e269da2e9e0444eb2d91499a5b27d86 |
| institution | Kabale University |
| issn | 1609-4042 2521-3407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj-art-6e269da2e9e0444eb2d91499a5b27d862025-01-22T01:21:10ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072025-01-0138110.30526/38.1.3357Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand ComplexesElaf A. Mousa0https://orcid.org/0000-0001-6447-529XBasim I. Al-Abdaly1https://orcid.org/0000-0001-7111-3959Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq. Transition ion complexes have various commercial and technical uses, including antibacterial, antifungal, and anticancer medications and catalysts; their characteristics are critical regarding their kinetic impact. This study aims to synthesize new complexes, copper and nickel complexes, characterize them using spectral techniques, determine their chloride content, evaluate their anti-oxidant effect, and examine the antibacterial activity of the ligands and their complexes against gram-positive bacteria (Staphylococcus), gram-negative bacteria (Escherichia coli), and Candida albicans. All chemicals were used strictly as provided, with no additional purification; CuCl2.2H2O and Ni(CH3CO2)2 salts were used to react with melatonin (L1), and one of the amino acids (L-cysteine) (L2) in a mole ratio of 1:1:1 (M: L1:L2) to produce mixed ligand metal complexes. The results showed that the two metal complexes were more active in (10–3 M) and had higher activity than the two ligands (melatonin and cysteine). According to the findings, the complexes have suggested structures: octahedral geometry for the Cu(II) complex and tetrahedral geometry for the Ni(II) complex. The scientific results demonstrated that the synthesized complexes have high antibacterial action against [Escherchiacoli (G-) (E. coli), Staphylococcus aureus (G+)], and antifungal action against [Candida (C. albicaus)]. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3357Antimicrobialcopper complexcysteinenickel complexmixed ligand |
| spellingShingle | Elaf A. Mousa Basim I. Al-Abdaly Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes Ibn Al-Haitham Journal for Pure and Applied Sciences Antimicrobial copper complex cysteine nickel complex mixed ligand |
| title | Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes |
| title_full | Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes |
| title_fullStr | Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes |
| title_full_unstemmed | Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes |
| title_short | Synthesis and Anti-microbial Activities Investigation of New Mixed Ligand Complexes |
| title_sort | synthesis and anti microbial activities investigation of new mixed ligand complexes |
| topic | Antimicrobial copper complex cysteine nickel complex mixed ligand |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3357 |
| work_keys_str_mv | AT elafamousa synthesisandantimicrobialactivitiesinvestigationofnewmixedligandcomplexes AT basimialabdaly synthesisandantimicrobialactivitiesinvestigationofnewmixedligandcomplexes |