Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review
Background: Voltage-gated sodium channels (Nav) are critical for generating action potentials in neuronal and muscle tissues. Dysfunction of these channels is associated with neurological disorders such as epilepsy, neuropathic pain, and myopathies. Although plant-derived compounds have shown promis...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001982 |
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| author | José Luis Estela-Zape Mayra Liliana Pizarro-Loaiza Gabriel Arteaga Santiago Castaño Leonardo Fierro |
| author_facet | José Luis Estela-Zape Mayra Liliana Pizarro-Loaiza Gabriel Arteaga Santiago Castaño Leonardo Fierro |
| author_sort | José Luis Estela-Zape |
| collection | DOAJ |
| description | Background: Voltage-gated sodium channels (Nav) are critical for generating action potentials in neuronal and muscle tissues. Dysfunction of these channels is associated with neurological disorders such as epilepsy, neuropathic pain, and myopathies. Although plant-derived compounds have shown promise in modulating Nav channels, the molecular mechanisms remain insufficiently understood. This systematic review aims to identify plant metabolites that affect Nav channel activity, with the potential for developing more selective and safer treatments. Methods: The review followed PRISMA 2020 guidelines. A search was conducted in three databases (PubMed, Scopus, Web of Science) using keywords related to sodium channels and medicinal plants. Studies were selected based on predefined eligibility criteria and evaluated through a standard critical appraisal process by two reviewers. Results: Six studies were included, examining the effects of plant metabolites on Nav channels. Isoquinoline alkaloids from Corydalis yanhusuo, hangeshashinto, osthol, and cannabidiol inhibited Na+ currents in cell models, primarily affecting Nav1.7 and Nav1.5. These compounds exhibited analgesic, antiarrhythmic, and neuroprotective properties, suggesting their therapeutic potential for disorders linked to Nav channel dysfunction. Conclusions: Plant-derived metabolites that modulate Nav channels present significant therapeutic potential for treating neurological disorders, offering more targeted treatments with fewer side effects. However, further research is needed to clarify the underlying molecular mechanisms and validate these compounds through preclinical and clinical trials. |
| format | Article |
| id | doaj-art-6e25269006b046228605cdfa549b118a |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-6e25269006b046228605cdfa549b118a2025-02-10T04:35:18ZengElsevierPhytomedicine Plus2667-03132025-02-0151100724Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic reviewJosé Luis Estela-Zape0Mayra Liliana Pizarro-Loaiza1Gabriel Arteaga2Santiago Castaño3Leonardo Fierro4Department of Physiological Sciences, Faculty of Health, Universidad del Valle, Santiago de Cali 760043, Colombia; Laboratorio de Herpetología y Toxinología, Department of Physiological Sciences - Universidad del Valle, Santiago de Cali 760043, Colombia; Facultad de Salud, Universidad Santiago de Cali, Cali 760035, ColombiaGrupo de Investigación Clínica en Psicología Neuropsicología y Neuropsiquiatría, Faculty of Psychology – Universidad del Valle, Santiago de Cali 760043, Colombia; Faculty of Dentistry, Antonio Nariño University (Palmira), Palmira 763531, Colombia; Correspondence author at: Calle 4B # 36-00, Santiago de Cali 760043, Valle del Cauca, Colombia.Grupo de Investigación Clínica en Psicología Neuropsicología y Neuropsiquiatría, Faculty of Psychology – Universidad del Valle, Santiago de Cali 760043, ColombiaDepartment of Physiological Sciences, Faculty of Health, Universidad del Valle, Santiago de Cali 760043, Colombia; Laboratorio de Herpetología y Toxinología, Department of Physiological Sciences - Universidad del Valle, Santiago de Cali 760043, ColombiaDepartment of Physiological Sciences, Faculty of Health, Universidad del Valle, Santiago de Cali 760043, Colombia; Laboratorio de Herpetología y Toxinología, Department of Physiological Sciences - Universidad del Valle, Santiago de Cali 760043, ColombiaBackground: Voltage-gated sodium channels (Nav) are critical for generating action potentials in neuronal and muscle tissues. Dysfunction of these channels is associated with neurological disorders such as epilepsy, neuropathic pain, and myopathies. Although plant-derived compounds have shown promise in modulating Nav channels, the molecular mechanisms remain insufficiently understood. This systematic review aims to identify plant metabolites that affect Nav channel activity, with the potential for developing more selective and safer treatments. Methods: The review followed PRISMA 2020 guidelines. A search was conducted in three databases (PubMed, Scopus, Web of Science) using keywords related to sodium channels and medicinal plants. Studies were selected based on predefined eligibility criteria and evaluated through a standard critical appraisal process by two reviewers. Results: Six studies were included, examining the effects of plant metabolites on Nav channels. Isoquinoline alkaloids from Corydalis yanhusuo, hangeshashinto, osthol, and cannabidiol inhibited Na+ currents in cell models, primarily affecting Nav1.7 and Nav1.5. These compounds exhibited analgesic, antiarrhythmic, and neuroprotective properties, suggesting their therapeutic potential for disorders linked to Nav channel dysfunction. Conclusions: Plant-derived metabolites that modulate Nav channels present significant therapeutic potential for treating neurological disorders, offering more targeted treatments with fewer side effects. However, further research is needed to clarify the underlying molecular mechanisms and validate these compounds through preclinical and clinical trials.http://www.sciencedirect.com/science/article/pii/S2667031324001982Voltage-gated sodium channelsMedicinal plantsPhytomedicinePhytochemicalPhytotherapyHerbal medicine |
| spellingShingle | José Luis Estela-Zape Mayra Liliana Pizarro-Loaiza Gabriel Arteaga Santiago Castaño Leonardo Fierro Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review Phytomedicine Plus Voltage-gated sodium channels Medicinal plants Phytomedicine Phytochemical Phytotherapy Herbal medicine |
| title | Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review |
| title_full | Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review |
| title_fullStr | Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review |
| title_full_unstemmed | Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review |
| title_short | Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review |
| title_sort | metabolites derived from medicinal plants modulating voltage gated sodium channel activity a systematic review |
| topic | Voltage-gated sodium channels Medicinal plants Phytomedicine Phytochemical Phytotherapy Herbal medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001982 |
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