Dosage sensitivity shapes the evolution of copy-number varied regions.

Dosage sensitivity shapes the evolution of copy-number varied regions.

Dosage sensitivity is an important evolutionary force which impacts on gene dispensability and duplicability. The newly available data on human copy-number variation (CNV) allow an analysis of the most recent and ongoing evolution. Provided that heterozygous gene deletions and duplications actually...

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Bibliographic Details
Main Authors: Benjamin Schuster-Böckler, Donald Conrad, Alex Bateman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009474&type=printable
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