MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1

MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1

Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug resistance-associated protein 2 (MRP2) is a transporter responsible for independent bile flow. Emerging evidence indicates that PDZ domain containing 1 (PDZK1) regulates localizati...

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Bibliographic Details
Main Authors: Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang
Format: Article
Language:English
Published: Compuscript Ltd 2025-02-01
Series:Acta Materia Medica
Subjects:
mir-128-3p
estrogen-induced cholestasis
mrp2
pdzk1
localization
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0053
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